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Table 3 Associations of genetically predicted bioavailable testosterone in men and of genetically predicted total testosterone in women with hemoglobin and HDL-cholesterol for validation of the genetic instrument in the UK Biobank

From: The role of testosterone in chronic kidney disease and kidney function in men and women: a bi-directional Mendelian randomization study in the UK Biobank

Outcome Exposure #SNPs Sex Methods Beta 95% CI p
Hemoglobin Genetically predicted bioT 119 Men MR-PRESSO 0.30 0.26, 0.33 8.3 × 10−31
WM 0.33 0.28, 0.37 2.0 × 10−48
Genetically predicted TT 252 Women MR-PRESSO 0.05 0.03, 0.08 8.6 × 10−5
WM 0.03 − 0.002, 0.06 0.07
HDL-cholesterol Genetically predicted bioT 119 Men MR-PRESSO − 0.07 − 0.10, − 0.04 4.0 × 10−5
WM − 0.08 − 0.12, − 0.04 4.1 × 10−5
Genetically predicted TT 252 Women MR-PRESSO − 0.06 − 0.09, − 0.04 1.2 × 10−6
WM − 0.05 − 0.09, − 0.02 0.003
  1. HDL high-density lipoprotein, IVW inverse variance weighting, WM weighted median, MR-PRESSO Mendelian randomization pleiotropy residual sum and outlier