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Fig. 2 | BMC Medicine

Fig. 2

From: Serum metabolite profiles are associated with the presence of advanced liver fibrosis in Chinese patients with chronic hepatitis B viral infection

Fig. 2

Workflow chart of feature selection. For a total of 98 metabolites (including AAs, BAs, and FFAs), univariate analyses (Wilcoxon’s rank-sum test) were employed for three clinical aims (aim 1: CLD vs. NC, aim 2: cirrhosis vs. fibrosis, aim 3: early fibrosis vs. advanced fibrosis). Twenty-six metabolites with p < 0.001 in all three clinical aims were selected and fed into LASSO and random forest algorithms for three aims. The overlap of top 5 LASSO non-zero coefficients and top 5 important variables from random forest (by mean decrease of accuracy) was selected. For aim 2 and aim 3, we selected the overlapped variables and combined with variables selected from aim 1 to yield the final panel four metabolites. “OR” means the union of two sets, and “AND” means the intersection of two or more sets

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