Fig. 3

Metabolite marker panel and model 1 for CLD with chronic HBV infection diagnosis. a Comparison of the four markers between CLD patients and NC in cohorts 1 and 2. b Waterfall plot of RF score and corresponding heatmap for the four markers in all datasets. c ROC curves of model 1 (RF model constructed with four markers), APRI, AST/ALT, and FIB-4 in cohort 1. d PR curves of model 1, APRI, AST/ALT, and FIB-4 in cohort 1. e ROC curves of model 1, APRI, AST/ALT, and FIB-4 in cohort 2 validation set. f PR curves of model 1, APRI, AST/ALT, and FIB-4 in cohort 2 validation set. g The diagnosis RF score in NC and CLD patients in training and validation sets. ***p < 0.001, Wilcoxon’s rank-sum test. The optimal cutoff value of the RF score was 0.434