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Table 1 Demographic and clinical data of patients with CLD and NC in cohort 1 (training set) and cohort 2 (validation set)

From: Serum metabolite profiles are associated with the presence of advanced liver fibrosis in Chinese patients with chronic hepatitis B viral infection

DatasetCohort 1 training setCohort 2 validation set
GroupControlCLDS0–2S3–4FibrosisCirrhosisControlCLDS0–2S3–4FibrosisCirrhosis
n50250434915540010490300134166141159
Sex (M/F)365/137361/143257/92104/51299/10162/4259/31202/9881/53121/45*86/55116/43*
Age (year)36.65 ± 11.7336.58 ± 11.8833.23 ± 9.9544.88 ± 12.22***34.05 ± 10.3148.65 ± 11.51***47.13 ± 9.9547.96 ± 13.2841.55 ± 12.8353.14 ± 11.26***41.21 ± 12.7253.95 ± 10.67***
BMI (kg/m2)23.08 ± 3.1622.28 ± 3.18***22.02 ± 3.2622.91 ± 2.91**22.15 ± 3.2222.87 ± 2.97*22.35 ± 1.8323.18 ± 3.13*23.28 ± 2.4823.1 ± 3.6123.21 ± 2.4923.15 ± 3.65
APRI0.09 ± 0.040.79 ± 1.33***0.6 ± 0.811.27 ± 2.08***0.63 ± 0.921.55 ± 2.4** 0.65 ± 0.70.61 ± 0.780.69 ± 0.57**0.6 ± 0.760.72 ± 0.58***
AST/ALT0.82 ± 0.320.69 ± 0.44***0.6 ± 0.310.94 ± 0.59***0.61 ± 0.331.1 ± 0.63*** 1.09 ± 0.60.98 ± 0.571.24 ± 0.61***0.97 ± 0.571.27 ± 0.61***
FIB-40.62 ± 0.332.86 ± 7.21***1.42 ± 1.486.57 ± 12.71***1.56 ± 1.79.42 ± 15.8*** 3.64 ± 3.642.49 ± 2.585.26 ± 4.27***2.45 ± 2.535.54 ± 4.3***
ALT (IU/L)30.97 ± 15.63176.49 ± 199.81***195.3 ± 213.41128.51 ± 150.32***193.08 ± 208.2794.18 ± 121.97***17.92 ± 7.7981.57 ± 117.77***111.4 ± 141.3957.2 ± 87.35***108.45 ± 138.5857.43 ± 89.06***
AST (IU/L)21.81 ± 6.8493.21 ± 99.71***95.65 ± 100.2386.98 ± 98.4796.32 ± 102.0177.75 ± 86.3220.25 ± 4.3768.73 ± 73.78***85.6 ± 91.4854.95 ± 51.62*83.2 ± 89.8255.74 ± 52.57
TBIL (μmol/L)15.5 ± 4.8427.73 ± 32.98***21.75 ± 13.2742.87 ± 55.62***23.06 ± 20.6450.58 ± 61.18***13.98 ± 3.6233.67 ± 47.77***23.77 ± 38.441.77 ± 52.99***23.54 ± 37.4542.77 ± 53.94***
ALP (IU/L)85.57 ± 19.1889.72 ± 76.2681.3 ± 65.24111.05 ± 95.86**82.37 ± 61.46125.77 ± 119.98**77.82 ± 19.2193.68 ± 70.86*70.57 ± 55.75112.56 ± 76.25***70.97 ± 54.47114.08 ± 77.53***
GGT (IU/L)17.12 ± 10.7269.18 ± 97.06***61.13 ± 69.7589.73 ± 143.43*66.72 ± 74.5581.42 ± 169.4626.26 ± 19.0776.87 ± 82.16***77.22 ± 83.5876.59 ± 81.2376.14 ± 81.7777.53 ± 82.76
TP (g/L)74.41 ± 4.7673.47 ± 8.55*75.68 ± 5.3167.87 ± 12.03***75.42 ± 5.2463.82 ± 13.76***73.65 ± 3.1971.31 ± 17.94***72.89 ± 5.8469.97 ± 23.74***73.07 ± 5.8269.66 ± 24.23***
ALB (g/L)49.23 ± 2.7740.19 ± 5.91***42.14 ± 3.3735.23 ± 7.81***41.75 ± 3.5432.47 ± 8.67***44.92 ± 2.1937.86 ± 7.18***41.44 ± 4.7934.93 ± 7.48***41.39 ± 4.7134.69 ± 7.54***
TBA (μmol/L)4.67 ± 3.1828.47 ± 45.11***20.33 ± 37.2849.68 ± 55.81***21.3 ± 36.4465.41 ± 63.96***3.6 ± 2.6343.41 ± 55.16***25.05 ± 37.8658.89 ± 62.37***24.33 ± 37.0461.11 ± 62.91***
PLT (109/L)261.02 ± 65.25164.52 ± 61.7***184.2 ± 47.74114.68 ± 65.05***179.06 ± 49.8693.23 ± 64.82*** 132.44 ± 62.97163.58 ± 51106.03 ± 60.14***161.54 ± 51.18105.27 ± 60.9***
Collagen proportionate area 7.46 ± 4.011.96 ± 1.439.95 ± 6.03***2.71 ± 2.4515.17 ± 7.11***      
HBV-DNA (log10) 6.25 ± 2.426.32 ± 2.445.99 ± 2.346.33 ± 2.385.39 ± 2.66      
Negative HbeAg, n 1911157614249      
Negative HbeAb, n 2231537017548      
Negative HbsAg, n 29245263      
  1. Values are expressed as mean ± SD
  2. ALT alanine transaminase, AST aspartate transaminase, TBIL total bilirubin, ALP alkaline phosphatase, GGT gamma-glutamyl transferase, ALB albumin, TBA total bile acid, PLT platelet
  3. *p < 0.05, **p < 0.01, ***p < 0.001, by Student’s t test, CLD vs. NC, S3–4 vs. S0–2, cirrhosis vs. fibrosis