Table 2 Risk of incident dementia in relation to 5 units higher body mass index measured at different age categories in the Swedish Twin Registry

Main model^a

1.10 (0.98–1.23)

1.15 (1.07–1.24)

1.11 (1.01–1.22)

0.96 (0.90–1.01)

0.90 (0.81–1.00)

Main model, genotyped^a

1.18 (0.96–1.44)

1.12 (0.98–1.26)

0.99 (0.87–1.12)

0.94 (0.85–1.03)

0.87 (0.75–1.01)

 PGS_BMI^b

1.20 (0.98–1.47)

1.12 (0.99–1.28)

0.98 (0.86–1.12)

0.93 (0.84–1.02)

0.88 (0.75–1.03)

 PGS_BMI and PGS_AD^c

1.14 (0.94–1.40)

1.13 (0.99–1.29)

0.98 (0.86–1.13)

0.94 (0.85–1.04)

0.88 (0.75–1.03)

 Lowest tertile

1.28 (0.91–1.80)

1.38 (1.08–1.78)

1.11 (0.87–1.42)

0.91 (0.76–1.09)

1.13 (0.86–1.47)

 Middle tertile

1.20 (0.85–1.70)

1.12 (0.89–1.40)

0.91 (0.72–1.16)

0.87 (0.73–1.03)

0.79 (0.60–1.04)

 Highest tertile

1.11 (0.79–1.56)

0.98 (0.79–1.20)

0.96 (0.78–1.19)

0.97 (0.84–1.13)

0.70 (0.52–0.94)

p value interaction

0.55

0.04

0.44

0.50

0.01

 All twins

1.06 (0.75–1.48)

1.21 (0.97–1.50)

1.18 (0.94–1.49)

0.90 (0.77–1.05)

1.16 (0.82–1.64)

 Dizygotic twins

1.06 (0.73–1.54)

1.25 (0.98–1.60)

1.24 (0.96–1.61)

0.93 (0.79–1.10)

1.15 (0.78–1.69)

 Monozygotic twins

1.03 (0.47–2.27)

1.07 (0.68–1.68)

0.98 (0.59–1.63)

0.76 (0.50–1.15)

1.19 (0.53–2.65)