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Table 2 Mediation analysis of the relationship between number of child maltreatment and CVD

From: Child maltreatment and cardiovascular disease: quantifying mediation pathways using UK Biobank

 

Outcome modela

Mediator modelb

Percent mediated

P

HR (95% CI)

P

OR/β (95% CI)

P

Short sleeper

1.24 (1.10, 1.41)

0.0007

1.14 (1.11, 1.18)

< 0.0001

2.4

0.04

Smoker/ex-smoker

1.13 (1.07, 1.20)

< 0.0001

1.20 (1.18, 1.21)

< 0.0001

14.7

0.02

Obesity

1.15 (1.08, 1.22)

< 0.0001

1.04 (1.03, 1.06)

< 0.0001

2.0

0.07

TV viewing time

1.03 (1.00, 1.06)

0.03

0.00 (− 0.01, 0.00)

0.13

–

–

Systolic blood pressure

1.12 (1.09, 1.15)

< 0.0001

− 0.02 (− 0.02, − 0.01)

< 0.0001

–

–

Handgrip strength

0.96 (0.93, 1.00)

0.08

0.00 (− 0.01, 0.00)

0.69

–

–

Depressive symptom

1.18 (1.16, 1.21)

< 0.0001

0.22 (0.22, 0.23)

< 0.0001

56.2

< 0.0001

HDL cholesterol

0.85 (0.82, 0.88)

< 0.0001

− 0.02 (− 0.02, − 0.01)

< 0.0001

8.7

0.03

Glycated haemoglobin

1.10 (1.08, 1.12)

< 0.0001

0.00 (0.00, 0.01)

0.31

–

–

Cystatin C

1.09 (1.07, 1.11)

< 0.0001

0.00 (0.00, 0.01)

0.10

–

–

Gamma-glutamyltransferase

1.05 (1.03, 1.07)

< 0.0001

0.00 (0.00, 0.01)

0.28

–

–

  1. ORs were presented for short sleeper, smoker/ex-smoker, and obesity
  2. aOutcome model: CVD regressed by potential mediators
  3. bMediator model: potential mediator regressed by child maltreatment