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Table 2 Mediation analysis of the relationship between number of child maltreatment and CVD

From: Child maltreatment and cardiovascular disease: quantifying mediation pathways using UK Biobank

 Outcome modelaMediator modelbPercent mediatedP
HR (95% CI)POR/β (95% CI)P
Short sleeper1.24 (1.10, 1.41)0.00071.14 (1.11, 1.18)< 0.00012.40.04
Smoker/ex-smoker1.13 (1.07, 1.20)< 0.00011.20 (1.18, 1.21)< 0.000114.70.02
Obesity1.15 (1.08, 1.22)< 0.00011.04 (1.03, 1.06)< 0.00012.00.07
TV viewing time1.03 (1.00, 1.06)0.030.00 (− 0.01, 0.00)0.13
Systolic blood pressure1.12 (1.09, 1.15)< 0.0001− 0.02 (− 0.02, − 0.01)< 0.0001
Handgrip strength0.96 (0.93, 1.00)0.080.00 (− 0.01, 0.00)0.69
Depressive symptom1.18 (1.16, 1.21)< 0.00010.22 (0.22, 0.23)< 0.000156.2< 0.0001
HDL cholesterol0.85 (0.82, 0.88)< 0.0001− 0.02 (− 0.02, − 0.01)< 0.00018.70.03
Glycated haemoglobin1.10 (1.08, 1.12)< 0.00010.00 (0.00, 0.01)0.31
Cystatin C1.09 (1.07, 1.11)< 0.00010.00 (0.00, 0.01)0.10
Gamma-glutamyltransferase1.05 (1.03, 1.07)< 0.00010.00 (0.00, 0.01)0.28
  1. ORs were presented for short sleeper, smoker/ex-smoker, and obesity
  2. aOutcome model: CVD regressed by potential mediators
  3. bMediator model: potential mediator regressed by child maltreatment