TY - JOUR AU - Gilchrist, James J. AU - Uyoga, Sophie AU - Pirinen, Matti AU - Rautanen, Anna AU - Mwarumba, Salim AU - Njuguna, Patricia AU - Mturi, Neema AU - Hill, Adrian V. S. AU - Williams, Thomas N. AU - Scott, J. Anthony G. AU - Chapman, Stephen J. AU - Rautanen, Anna AU - Mills, Tara C. AU - Rockett, Kirk AU - Ndungu, Anne W. AU - Naranbhai, Vivek AU - Macharia, Alex W. AU - Uyoga, Sophie AU - Ndila, Carolyne AU - Mturi, Neema AU - Njuguna, Patricia AU - Mohammed, Shebe AU - Berkley, James A. AU - Mwangi, Isaiah AU - Mwarumba, Salim AU - Kitsao, Barnes S. AU - Lowe, Brett S. AU - Morpeth, Susan C. AU - Khandwalla, Iqbal AU - Opi, Herbert AU - Nyatichi, Emily AU - Ingosi, Prophet AU - Kitsao, Barnes AU - Lewa, Clement AU - Makale, Johnstone AU - Mohamed, Adan AU - Magua, Kenneth AU - Njoroge, Mary AU - Nyutu, Gideon AU - Mwarabu, Ruth AU - Tendwa, Metrine AU - Ahmed, Ismail AU - Akech, Samuel AU - Makazi, Alexander Balo AU - Hajj, Mohammed Bakari AU - Brent, Andrew AU - Chesaro, Charles AU - Dayo, Hiza AU - Idro, Richard AU - Kosgei, Patrick AU - Maitland, Kathryn AU - Marsh, Kevin AU - Mwalekwa, Laura AU - Mwaringa, Shalton AU - Newton, Charles AU - Ngama, Mwanajuma AU - Pamba, Allan AU - Peshu, Norbert AU - Seale, Anna AU - Talbert, Alison AU - Hill, Adrian V. S. AU - Scott, J. Anthony G. AU - Williams, Thomas N. AU - The Kenyan Bacteraemia Study Group PY - 2020 DA - 2020/06/15 TI - Risk of pneumococcal bacteremia in Kenyan children with glucose-6-phosphate dehydrogenase deficiency JO - BMC Medicine SP - 148 VL - 18 IS - 1 AB - Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency state in humans. The clinical phenotype is variable and includes asymptomatic individuals, episodic hemolysis induced by oxidative stress, and chronic hemolysis. G6PD deficiency is common in malaria-endemic regions, an observation hypothesized to be due to balancing selection at the G6PD locus driven by malaria. G6PD deficiency increases risk of severe malarial anemia, a key determinant of invasive bacterial disease in malaria-endemic settings. The pneumococcus is a leading cause of invasive bacterial infection and death in African children. The effect of G6PD deficiency on risk of pneumococcal disease is undefined. We hypothesized that G6PD deficiency increases pneumococcal disease risk and that this effect is dependent upon malaria. SN - 1741-7015 UR - https://doi.org/10.1186/s12916-020-01604-y DO - 10.1186/s12916-020-01604-y ID - Gilchrist2020 ER -