Fig. 3

The association between circulating mRNAs in the maternal circulation and fetal acidemia. Those with preterm fetal growth restriction in the FOX study were examined. Maternal bloods were taken within 2 h of birth and fetal pH (pH < 7.2 is defined as fetal acidemia) taken from the umbilical artery shortly after birth. a The spread of umbilical artery pH concentrations in the FOX cohort. Red dot is the median value. b–d Expression levels of three circulating RNAs. For PTGDR2 p = 0.07. e The receiver operated curve when circulating NRA2, RCBTB2, and PTGDR2 in the maternal circulation are combined to detect fetal acidemia (pH < 7.2). The area under the receiver operated curve (AUC) was 0.74 (95% CI 0.59–0.89). *p < 0.05