From: Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion disease
PRNPmutation carriers | Non-carrier controls | ||||
N | 27 | 16 | |||
Age at the first visit | 44.2 ± 15.2 | 44.5 ± 12.7 | |||
Sex | Male | 10 | 5 | ||
Female | 17 | 11 | |||
PRNPgenotype | Wild type | 0 | 16 | ||
E200K | 12 | 0 | |||
D178N | 7 | 0 | |||
P102L | 4 | 0 | |||
Other | 4 | 0 | |||
Number of completed study visits | 1 visit | 7 | 4 | ||
2 visits | 9 | 9 | |||
3 visits | 11 | 3 | |||
PRNPmutation carriers | Non-carrier controls | pvalue | pvalue (Bonferroni corrected) | ||
Assessments | MRC prion disease rating scale | 20.0 ± 0.0 | 20.0 ± 0.0 | 1 | 1 |
Montreal cognitive assessment | 27.7 ± 1.6 | 28.5 ± 1.7 | 0.20 | 1 |