Table 1 Characteristics of included reviews
First author | Year | Population | Total no. of patients | Total no. of trials | Proportion transfused RBCs | Mean difference in units transfused | Describes timing of intervention | Mortality time points pooled in meta-analyses | Subgroups presented for mortality outcome |
|---|---|---|---|---|---|---|---|---|---|
Brunskill | 2015 | Patients undergoing surgery for hip fracture | 2722 | 6 | R: 38%, L: 96%* | NR | Y | 30-day; 60-day; 90-day | Â |
Carson | 2018 | Adults or children admitted for surgical or medical care | 19,049 | 37 | R: 50%, L: 81% | NR | N | 30-day | Total; cardiac surgery; acute myocardial infarction |
Chong | 2018 | Adult surgical or critically ill patients | 10,797 | 27 | NR | Critical care 1.7, surgical 1.3 | N | 30-day; late mortality (60 to 365 days); in-study | Critical care; surgical |
Cortes-Puch | 2018 | Patients with and without cardiovascular disease | 14,397 | 17 | NR | NR | N | 30-day or in-hospital | Cardiovascular disease patients hospitalised for non-cardiac reasons; for percutaneous coronary interventions; for cardiac surgery |
Docherty | 2016 | Adults with cardiovascular disease not undergoing cardiac surgery | 3033 | 11 | R: 41%, L: 96%* | NR | N | 30-day | Total; Stratified by cardiovascular disease |
Gu | 2018 | Adult patients undergoing orthopaedic surgery | 3968 | 10 | NR | NR | N | 30-day | Â |
Holst | 2015 | Adults or children admitted for surgical or medical care | 9813 | 31 | R: 45%, L: 86% | 1.43 | N | Mixed (unspecified) | Low risk of bias trials |
Hovaguimian | 2016 | Adult surgical or critically ill patients | 12,052 | 31 | NR | NR | N | Within 30 days | Cardiovascular disease undergoing cardiac or vascular procedures; patients with cardiovascular disease undergoing orthopaedic surgery; surgical and medical patients admitted to an acute care facility |
Kheiri | 2018 | Patients undergoing cardiac surgery | 9005 | 9 | R: 52%, L: 76% | NR | Y | Within 30 days |  |
Luo | 2018 | Haematology/oncology | 733 | 5 | NR | 0.33 | N | 60-day | Â |
Mao | 2017 | Adults undergoing hip or knee surgery | 3788 | 10 | R: 36%, L: 74% | NR | N | 30-day | Â |
Melchor | 2016 | Critically ill adults admitted to intensive care units and/or with acute coronary syndrome | 2159 | 6 | R: 63%, L: 99% | NR | Y | Mixed (longest term) | Critical care; coronary artery disease |
Mitchell | 2017 | Adults undergoing hip or knee surgery or hip fracture repair | 3783 | 9 | R: 39%, L: 81% | 0.95 | N | Mixed (unspecified) | Â |
Muller | 2018 | Patients undergoing major orthopaedic surgery | 3693 | 8 | R: 36%, L: 82% | NR | N | 30-day | Â |
Odutayo | 2017 | Patients 16 years and older with acute upper gastrointestinal bleeding | 1965 | 5 | NR | 1.73 | N | Mixed |  |
Patel | 2015 | Adult patients undergoing cardiac surgery, adult and paediatric critically ill or noncardiac surgical patients | 11,713 | 25 | NR | NR | N | 30-day | Cardiac surgery; non-cardiac surgery |
Salpeter | 2014 | Adults or children admitted for surgical or medical care | 2364 | 3 | NR | 1.98 | N | In-hospital, 30-day, total | Â |
Shehata | 2018 | Adults or paediatric patients undergoing cardiac surgery | 9092 | 13 | R: 53%, L: 78% | 0.90 | Y | Within 30 days | Adult patients; paediatric patients |
Simon | 2017 | Adults admitted for surgical or medical care where a substantial proportion of the trial population was older than 65 years | 5780 | 9 | R: 52%, L: 77%* | NR | N | 30-day; 90-day |  |