Fig. 1

Schematic diagram of the phenotype and function of quasi-regulatory T cells in pancreatic adenocarcinoma. The quasi-regulatory T cells exist during pancreatic tumorigenesis through the upregulation of FOXP3 and downregulation of EHF, with specific surface markers (PD-L1 high and E-Cadherin low) and secreted cytokine profiles (TGF-β, IL-35, GM-CSF). Those cells play important roles in immune evasion, angiogenesis, and metastasis of pancreatic adenocarcinoma