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Table 1 MDR-TB cascade of care data sources and estimations, Madagascar, 2017

From: Multidrug-resistant tuberculosis surveillance and cascade of care in Madagascar: a five-year (2012–2017) retrospective study

Cascade stepMethods/data sourceReferencesTB all formsPresumptive MDR-TBMDR-TB
n (95% CI)n (95% CI)n (95% CI)
1. Prevalent cases• WHO
• National drug resistance survey
• National reference laboratory data
• NTP case notification data
[1, 2, 22, 23]61,880 (40,040–88,400)3646 (2258–5437)341 (61–913)
2. Reached diagnostic and treatment centre• Country tuberculosis guidelines
• Diagnostic literature
• Locally assessed sensitivity of sputum microscopy and GeneXpert MTB/RIF
• National reference laboratory data
• NTP case notification data
[17, 19, 20, 23,24,25]51,419 (46,744–57,250)3563 (3197–4046)224 (170–330)
3. Diagnosed• National reference laboratory data
• NTP case notification data
[23, 26]35,339 (35,124–35,570)2485 (2443–2540)24 (22–27)
4. Registered for treatment• NTP clinical management data[26]32,427 (−)2257 (−)18 (−)
5. Cured or treatment completed• NTP clinical management data[26]28,178 (−)1852 (−)8 (−)
6. Recurrence-free survival• NTP clinical management data
• Clinical TB literature
[26, 27]27,996 (27,774–28,108)1670 (1448–1782)8 (−)
  1. The cascade of care steps with references and total number of cases. Presumptive MDR-TB cases are included in TB all forms; MDR-TB cases are included in presumptive MDR-TB cases
  2. CI confidence interval, MDR-TB multidrug-resistant tuberculosis, MTB/RIF Mycobacterium tuberculosis/rifampicin, NTP national tuberculosis control programme, WHO World Health Organization
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