Fig. 4

Elimination and persistence for universal vaccination with a vaccine preventing (re-)infection and reactivation. CMV elimination is feasible for effectively vaccinated proportions and durations of protection above the curve, while below the curve CMV cannot be eliminated. The curves correspond to the effective reproduction number equal to 1. The parameter values used in Table 1 are depicted as the black circle (70% and 10 years). For all vaccination strategies, the longer the duration of protection, the smaller proportion of persons would need to be effectively vaccinated to eliminate CMV. Vaccination of females only at the age of 10 or 25 years would require a vaccine with a longer duration of protection for elimination than vaccination of both males and females at the age of 6 months or at 10 years (e.g., about 27 years vs 20 years if 60% of the target group are effectively vaccinated)