Table 1 Impact of interventions on cCMV, primary infection, and re-infection/reactivation
From: Short- and long-term impact of vaccination against cytomegalovirus: a modeling study
Intervention scenario | Â | Reduction % | Reduction % | Â | Â |
|---|---|---|---|---|---|
| Â | Reduction % | incidence | incidence | Effective | Â |
| Â | birth prevalence | primary | re-infection/ | reproduction | DALYs |
| Â | cCMV | infection | reactivation | number | prevented |
| Â | median (95%CrI) | median (95%CrI) | median (95%CrI) | median (95%CrI) | median (95%CrI) |
Universal vaccination | Â | Â | Â | Â | Â |
Prevention of (re-)infection and reactivation | Â | Â | Â | Â | Â |
6-month-old boys and girls | 5.4 (4.1–7.7) | 18.7 (16.6–21.9) | 5.2 (3.9–8.0) | 1.09 (0.98–1.20) | 1446 (1007–2304) |
10-year-old boys and girls | 11.7 (10.2–14.1) | 17.2 (15.2–20.3) | 7.0 (5.0–10.0) | 1.10 (0.98–1.21) | 3,558 (2731–4979) |
10-year-old girls | 10.8 (9.7–12.8) | 10.5 (9.1–13.2) | 4.7 (3.5–7.2) | 1.13 (1.01–1.26) | 3,267 (2515–4386) |
25-year-old women | 31.7 (30.6–33.6) | 9.9 (8.6–12.5) | 7.9 (6.5–10.8) | 1.11 (0.98–1.22) | 15,969 (12,560–19,993) |
Prevention of infection | Â | Â | Â | Â | Â |
6-month-old boys and girls | 3.2 (2.3–4.4) | 15.4 (13.9–17.7) | 2.4 (1.8–3.9) | 1.13 (1.01–1.24) | 788 (465–1091) |
10-year-old boys and girls | 5.6 (4.4-6.7) | 12.5 (11.0–14.3) | 2.2 (1.5–3.3) | 1.16 (1.04–1.28) | 1584 (1063–2087) |
10-year-old girls | 5.3 (4.2–6.0) | 7.0 (6.2–8.1) | 1.5 (1.0–2.3) | 1.19 (1.07–1.31) | 1500 (1012–1918) |
25-year-old women | 8.4 (6.6–10.7) | 4.5 (4.1–4.9) | 1.1 (0.9–1.5) | 1.25 (1.12–1.36) | 4227 (2646–4968) |
Vaccination during pregnancy | 71.4 (71.0–71.9) | 2.4 (0.3–4.8) | 5.9 (4.3–8.5) | 1.05 (0.92–1.18) | 49,705 (40,280–61,435) |
Hygienic measures | 1.8 (1.0–2.8) | 3.0 (2.5–4.0) | 0.9 (0.6–1.7) | 1.27 (1.13–1.38) | 819 (470–1278) |