Table 1 Baseline characteristic of study population
All patients (n = 85) | Stable mild group (n = 69) | Progression group (n = 16) | P value | |
|---|---|---|---|---|
Age, years | < 0.001 | |||
Mean ± SD | 46.6 ± 15.0 | 43.9 ± 14.0 | 58.2 ± 14.0 | |
Median, range | 46 (15–81) | 45 (15–80) | 62 (30–81) | |
Sex, Male | 49 (57.6) | 35 (50.7) | 14 (87.5) | 0.010 |
Symptoms | ||||
Fever | 71 (83.5) | 57 (82.5) | 14 (87.5) | 0.635 |
Cough | 47 (56.0) | 38 (55.1) | 9 (60.0) | 0.728 |
Expectoration | 29 (34.9) | 22 (32.4) | 7 (46.7) | 0.293 |
Fatigue | 39 (45.9) | 33 (47.8) | 6 (37.6) | 0.455 |
Dyspnea | 10 (11.8) | 5 (7.2) | 5 (31.3) | 0.018 |
Diarrhea | 10 (11.9) | 9 (13.2) | 1 (6.3) | 0.679 |
Headache | 5 (6.0) | 4 (5.9) | 1 (6.3) | 1.000 |
Laboratory examination | ||||
White blood count | 4.8 ± 1.9 | 4.8 ± 1.8 | 5.1 ± 2.2 | 0.602 |
Neutrophils | 3.2 ± 1.6 | 3.1 ± 1.6 | 3.5 ± 1.5 | 0.380 |
Lymphocytes | 1.2 ± 0.7 | 1.2 ± 0.6 | 1.1 ± 1.2 | 0.418 |
Hemoglobin | 135.7 ± 13.8 | 136.6 ± 13.6 | 132.3 ± 14.6 | 0.272 |
Platelets | 184.6 ± 68.1 | 190.2 ± 73.0 | 160.5 ± 33.0 | 0.117 |
ALT | 30.0 ± 68.1 | 29.0 ± 19.5 | 38.0 ± 14.1 | 0.517 |
AST | 31.3 ± 18.8 | 29.7 ± 19.5 | 38.0 ± 14.1 | 0.114 |
Creatine | 69.2 ± 22.7 | 64.8 ± 14.9 | 87.9 ± 37.8 | 0.029 |
Creatine kinase | 150.4 ± 236.9 | 136.1 ± 241.7 | 212.2 ± 211.0 | 0.250 |
Troponin T | 0.030 ± 0.309 | 0.024 ± 0.017 | 0.053 ± 0.054 | 0.052 |
Lactate dehydrogenase | 240.1 ± 84.3 | 222.4 ± 73.8 | 316.4 ± 86.4 | < 0.001 |
NT-proBNP | 85.7 ± 200.0 | 61.7 ± 79.3 | 189.6 ± 423.5 | 0.247 |
C-reactive protein | 23.6 ± 25.7 | 18.1 ± 20.2 | 47.0 ± 33.7 | 0.004 |
Radiology manifestation | 0.528 | |||
Normal | 4 (4.7) | 4 (5.8) | 0 (0%) | |
Unilateral involved | 8 (9.4) | 7 (10.1) | 1 (6.3) | |
Bilateral involved | 73 (85.9) | 58 (84.1) | 15 (93.5) | |
Chronic medical illness | ||||
Hypertension | 26 (30.6) | 17 (24.6) | 9 (56.3) | 0.032 |
Coronary heart disease | 1 (1.2) | 1 (1.4) | 0 (0%) | 1.000 |
Diabetes mellitus | 11 (12.9) | 9 (13.0) | 2 (12.5) | 1.000 |
Autoimmune disorders | 1 (1.2) | 1 (1.4) | 0 (0%) | 1.000 |
Chronic liver diseases | 9 (9.4) | 8 (11.6) | 0 (0%) | 0.174 |