Predictor | Adjusted HR (95% CI); p value |
---|---|
Gender | |
Male | 1.29 (1.12–1.48); 0.0003 |
Female | Referent |
Age (per year) | 1.09 (1.08–1.10); < 0.0001 |
Long-term opioid therapy | 1.58 (1.38–1.82); < 0.0001 |
Non-opioid therapy | Referent |
Duration of drug therapy (per month) | 0.996 (0.995–0.996); < 0.0001 |
Comorbidity index | 1.19 (1.16–1.23); < 0.0001 |
Estimated propensity score | 1.32 (0.96–1.81); 0.08 |
Index quarter | 0.998 (0.998–0.999); < 0.0001 |