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Table 2 Incremental impact of preventive therapy stratified by coverage in PLHIV, and household contacts of reported TB cases. Shown in the example of the ‘improved TB cascade’ comparator, results illustrate the overall impact arising from both of these eligible populations

From: The potential impact of preventive therapy against tuberculosis in the WHO South-East Asian Region: a modelling approach

 

Targeting PLHIV (%)

Targeting household contacts (%)

Total (%)

Reduction in annual incidence rate attributable to preventive therapy (2030 relative to 2015), under the improved cascade comparator

 Bangladesh

0.09 [0.05–0.14]

4.38 [3.71–4.49]

4.45 [3.79–5.60]

 Bhutan

0.10 [0.03–0.39]

3.17 [2.57–3.95]

3.25 [2.66–4.25]

 DPR Korea

0.09 [0.04–0.17]

8.69[−2.07–14.81]

8.79[−2.01–14.89]

 India

1.79 [1.14–2.91]

4.53 [3.56–5.79]

6.44 [5.08–8.33]

 Indonesia

1.53 [0.85–2.99]

6.35 [5.50–7.99]

7.81 [6.52–10.05]

 Maldives

0.03 [0.025–0.049]

1.94 [1.43–2.86]

1.97 [1.45–2.90]

 Myanmar

4.39 [2.70–7.69]

7.96 [6.04–15.50]

12.41 [9.02–23.00]

 Nepal

0.62 [0.44–0.94]

4.62 [3.60–6.96]

5.22 [4.12–7.78]

 Sri Lanka

0.20 [0.13–0.27]

1.95 [1.49–2.65]

2.15 [1.68–2.83]

 Thailand

5.69 [3.84–9.23]

3.40 [2.50–5.62]

9.06 [6.47–15.52]

 Timor Leste

1.06 [0.44–2.64]

21.29 [12.18–38.06]

22.39 [12.56–40.23]

 SEAR

1.81 [1.30–2.38]

5.14 [4.38–6.14]

6.93 [5.81–8.51]

Reduction in annual TB mortality attributable to preventive therapy (2030 relative to 2015), under the improved cascade comparator

 Bangladesh

0.03 [0.01–0.10]

1.67 [0.56–4.12]

1.70 [0.57–4.21]

 Bhutan

0.05 [0.008–0.28]

1.57 [0.43–4.49]

1.67 [0.43–4.63]

 DPR Korea

0.05 [0.02–0.14]

4.74[−1.13–14.81]

4.80[− 1.08–14.94]

 India

1.05 [0.58–1.88]

2.62 [1.59–4.29]

3.59 [2.48–6.07]

 Indonesia

0.61 [0.35–1.15]

2.57 [1.88–3.60]

3.19 [2.40–4.60]

 Maldives

0.001 [0.0007–0.0013]

0.07 [0.06–0.09]

0.07 [0.06–0.09]

 Myanmar

1.98 [0.93–3.79]

3.97 [1.76–7.67]

6.02 [2.81–11.26]

 Nepal

0.53 [0.15–1.54]

4.18 [1.02–11.47]

4.71 [1.17–13.02]

 Sri Lanka

0.09 [0.04–0.25]

0.97 [0.34–2.13]

1.06 [0.38–2.29]

 Thailand

1.92 [0.78–5.12]

1.15 [0.52–3.36]

3.03 [1.23–7.89]

 Timor Leste

0.39 [0.10–1.33]

9.00 [2.66–29.17]

9.47 [2.75–30.10]

 SEAR

0.94 [0.58–1.45]

2.60 [1.96–3.73]

3.52 [2.72–5.08]