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Table 2 Summary performance metrics for SeptiCyte™ scores, WCC and CRP for discrimination of proven bacterial and viral infections in the ED cohort, at the Youden index threshold for each test

From: Blood transcriptomic discrimination of bacterial and viral infections in the emergency department: a multi-cohort observational validation study

  SeptiCyte™ TRIAGE Combined SeptiCyte™ WCC CRP
ROC AUC 0.89 (0.81–0.97) 0.95 (0.90–1) 0.79 (0.68–0.91) 0.73 (0.61–0.86)
Sensitivity 0.87 (0.76–0.94) 0.94 (0.86–0.98) 0.84 (0.75–0.90) 0.87 (0.79–0.93)
Specificity 0.79 (0.5–0.95) 0.93 (0.66–0.99) 0.81 (0.54–0.96) 0.5 (0.25–0.75)
LR+ve 4.04 (1.50–19.48) 13.18 (2.53–546.5) 4.45 (1.64–22.24) 1.75 (1.05–3.77)
LR−ve 0.17 (0.10–0.48) 0.06 (0.02–0.22) 0.20 (0.10–0.46) 0.25 (0.09–0.84)
At prior probability of bacterial infection of 35%
PPVbacteria 0.66 (0.34–0.91) 0.88 (0.51–0.99) 0.70 (0.39–0.93) 0.35 (0.15–0.62)
NPVbacteria 0.70 (0.45–0.80) 0.86 (0.64–0.96) 0.90 (0.80–0.94) 0.88 (0.69–0.95)
At prior probability of bacterial infection of 72%
PPVbacteria 0.91 (0.79–0.98) 0.97 (0.87–0.99) 0.92 (0.80–0.98) 0.82 (0.73–0.91)
NPVbacteria 0.92 (0.79–095) 0.97 (0.90–0.99) 0.66 (0.46–0.79) 0.60 (0.32–0.72)
  1. Values in brackets represent the 95% confidence intervals. LR+ve likelihood ratio of bacterial infection for a positive result, LR−ve likelihood ratio of bacterial infection for a negative result, PPVbacteria positive predictive value for bacterial infection, NPVbacteria negative predictive value for bacterial infection