| |
SeptiCyte™ TRIAGE
|
Combined SeptiCyte™
|
WCC
|
CRP
|
|---|
|
ROC AUC
|
0.89 (0.81–0.97)
|
0.95 (0.90–1)
|
0.79 (0.68–0.91)
|
0.73 (0.61–0.86)
|
|
Sensitivity
|
0.87 (0.76–0.94)
|
0.94 (0.86–0.98)
|
0.84 (0.75–0.90)
|
0.87 (0.79–0.93)
|
|
Specificity
|
0.79 (0.5–0.95)
|
0.93 (0.66–0.99)
|
0.81 (0.54–0.96)
|
0.5 (0.25–0.75)
|
|
LR+ve
|
4.04 (1.50–19.48)
|
13.18 (2.53–546.5)
|
4.45 (1.64–22.24)
|
1.75 (1.05–3.77)
|
|
LR−ve
|
0.17 (0.10–0.48)
|
0.06 (0.02–0.22)
|
0.20 (0.10–0.46)
|
0.25 (0.09–0.84)
|
|
At prior probability of bacterial infection of 35%
|
|
PPVbacteria
|
0.66 (0.34–0.91)
|
0.88 (0.51–0.99)
|
0.70 (0.39–0.93)
|
0.35 (0.15–0.62)
|
|
NPVbacteria
|
0.70 (0.45–0.80)
|
0.86 (0.64–0.96)
|
0.90 (0.80–0.94)
|
0.88 (0.69–0.95)
|
|
At prior probability of bacterial infection of 72%
|
|
PPVbacteria
|
0.91 (0.79–0.98)
|
0.97 (0.87–0.99)
|
0.92 (0.80–0.98)
|
0.82 (0.73–0.91)
|
|
NPVbacteria
|
0.92 (0.79–095)
|
0.97 (0.90–0.99)
|
0.66 (0.46–0.79)
|
0.60 (0.32–0.72)
|
- Values in brackets represent the 95% confidence intervals. LR+ve likelihood ratio of bacterial infection for a positive result, LR−ve likelihood ratio of bacterial infection for a negative result, PPVbacteria positive predictive value for bacterial infection, NPVbacteria negative predictive value for bacterial infection
