Factor | Levels | Coding | ||
---|---|---|---|---|
1 | 2 | 3 | ||
Patient’s presenting symptoms [SYMPTOMS] | Symptoms indicating a urinary tract infection, with kidney pain. | Fever, cough and possible pulmonary infiltrates on chest X-ray. | Off-legs and confused. Possible urinary tract infection, possible lower respiratory tract infection. Might have experienced a fall [base level so variable not named]1. | Categorical variable—effects coded |
Whether early discontinuation of antibiotic treatment within 72 h of treatment initiation would be in conflict with local antibiotic guidelines [CONFLICT] | Early discontinuation would strongly conflict with local antibiotic guidelines. | Early discontinuation would somewhat conflict with local antibiotic guidelines. | Early discontinuation would not conflict with local antibiotic guidelines [base level so variable not named]1. | Categorical variable—effects coded |
Risk of significant harm arising from continued antibiotic treatment [CONTINUE RISK] | Likely. In 30 cases out of every 100 like this, the patient will experience an adverse effect from continued antibiotic treatment. | Somewhat likely. In 10 cases out of every 100 like this, the patient will experience an adverse effect from continued antibiotic treatment. | Negligible. In 1 case out of every 100 like this, the patient will experience an adverse effect from continued antibiotic treatment. | Assumed to be linear—coded as a continuous variable |
Risk of significant harm arising from discontinuing antibiotic treatment [STOP RISK] | Likely. In 30 cases out of every 100 like this, the patient will have a relapse, recurrence or readmission if antibiotic treatment is discontinued. | Somewhat likely. In 10 cases out of every 100 like this, the patient will have a relapse, recurrence or readmission if antibiotic treatment is discontinued. | Negligible. In 1 case out of every 100 like this, the patient will have a relapse, recurrence or readmission if antibiotic treatment is discontinued. | Assumed to be linear—coded as a continuous variable |
Premorbid condition of the patient [PREMORBID] | The patient has severe frailty and comorbidities. | The patient has moderate frailty and comorbidities. | The patient was previously fit and well [base level so variable not named]1. | Categorical variable—effects coded |
Level of external pressure to continue antibiotic treatment [EXTERNAL PRESSURE] | There is no external pressure to continue antibiotic treatment. | There is some external pressure to continue antibiotic treatment. | There is heavy external pressure to continue antibiotic treatment [base level so variable not named]1. | Categorical variable—effects coded |