Fig. 6

Fidaxomicin attenuates ZIKV-induced brain lesions. a Representative H/E staining of the cerebra specimens obtained from the mock infection group, the vehicle-control group, the 10 mg/kg fidaxomicin treatment group, and the 20 mg/kg fidaxomicin treatment group, respectively. Cerebra specimens were collected on the day of death or at the experimental endpoint. The perivascular infiltrates of mononuclear cells (“perivascular cuffing”) are indicated by black triangles. b Magnified images of the boxed areas in a, respectively. Black triangles show the perivascular cuffing; scale bar represents 500 μm. c Magnified images of the boxed areas in b, respectively. Red circles show the neuronal necrosis, and black triangles show the perivascular cuffing; scale bar represents 100 μm. d Quantification of the perivascular cuffing in whole cerebra tissue slices of the vehicle-control group and the fidaxomicin treatment groups (p value, compared to vehicle control)