Fig. 1
DNA methylation around HBV integration regions. a The enrichment score of CpGs in different genomic elements in 5 pilot WGBS. HBVi represents for HBV integration site. b The heatmap displays the methylation level of 2670 DMCs between HCC patient and healthy individual in all the 5 individuals. c The locus of 6 DMCs and 3 reported HBV integration sites in intron 2 of SENP5. The black dots represent the HBV integration sites and the orange vertical lines represent the 6 DMCs. The black bar labels represent the locus of repeat marker in this region. d The percentage of DMCs located at different genomic elements and regions surrounding HBV integration site. e The enrichment scores of DMCs at different genomic elements. f The average DNA methylation level profiles along 10 kb upstream and downstream of the HBV integration sites in buffy coat and tumor tissue of patient HOT170. The black dotted line represents 5 kb upstream or downstream of HBV integration sites. g The difference between buffy coat and tumor tissue of average methylation level across the genome (Methylgenome) and average methylation level of the CpGs within the 100 bp of HBV integration sites (MethylHBV)