Does parity matter in women’s risk of dementia? A COSMIC collaboration cohort study

Table 5 The risks of nulliparity and grand multiparity for dementia according to subtypes and geographical regions

	Numbers of subjects					All-cause dementia		AD		VaD		NAVD
	Control	Dementia	AD	VaD	NAVD	OR (95 CI)*	P	OR (95 CI)*	P	OR (95 CI)*	P	OR (95 CI)*	P
Nulliparity
Asia	239/5584	27/336	17/244	1/27	7/54	2.15 (1.33–3.47)	0.002	1.91 (1.07–3.39)	0.028	1.03 (0.13–7.89)	0.977	3.47 (1.44–8.35)	0.005
Europe	117/3098	25/125	12/88	1/22	1/12	0.70 (0.38–1.30)	0.261	0.90 (0.46–1.76)	0.761	0.28 (0.04–2.13)	0.218	0.53 (0.06–4.32)	0.552
Latin America	2456/270	32/245	15/129	4/24	13/89	0.91 (0.59–1.40)	0.661	0.72 (0.40–1.30)	0.277	1.39 (0.42–4.57)	0.585	1.11 (0.58–2.14)	0.746
Grand multiparity
Asia	919/5584	132/336	102/244	10/27	1/54	1.25 (0.94–1.67)	0.122	1.29 (0.93–1.79)	0.127	1.37 (0.55–3.42)	0.498	1.22 (0.61–2.43)	0.581
Europe	117/3098	39/125	6/88	3/22	1/12	2.99 (1.38–6.47)	0.005	2.42 (0.94–6.25)	0.068	6.86 (1.81–26.08)	0.005	3.36 (0.37–30.80)	0.283
Latin America	702/2456	70/245	30/129	9/24	28/89	1.49 (1.04–2.12)	0.028	1.25 (0.77–2.03)	0.366	1.41 (0.53–3.79)	0.495	1.80 (1.05–3.10)	0.034

AD Alzheimer’s disease, VaD vascular dementia, NAVD non-Alzheimer non-vascular dementia, OR odds ratio, CI confidence intervals
*Binary or multinomial logistic regression analyses that employed the women with 1 to 4 parities as the referent group and adjusted age, educational level, hypertension, diabetes mellitus, and cohort as covariates using the pooled dataset of 9 cohort studies that provided the type of dementia (Cuban Health and Alzheimer Study, Etude SanteÂ Psychologique et Traitement, Gothenburg H70 Birth cohort Studies, Hellenic Longitudinal Investigation of Aging and Diet, Korean Longitudinal Study on Cognitive Aging and Dementia, Kurihara Study, Leipzig Longitudinal Study of the Aged, Shanghai Aging Study, Sao Paulo Ageing & Health Study)

ISSN: 1741-7015