Fig. 3

Validation of the TMB estimation model based on the 89 early-stage NSCLC patients in the validation set. a The Pearson correlation coefficient of estimated TMB by the 23-gene panel and WES-TMB is 0.8487, with an empirical p value of r of p < 0.0001. b The disease-free survival is higher in the estimated TMB-high group (≥ 4 mutational counts, n = 18) than in the TMB-low group (< 4 mutational counts, n = 71), with log-rank test p < 0.05. c The overall survival is comparable in the two groups, with log-rank test p = 0.4458