Fig. 6

Immunotherapy response estimation by the 23-gene panel. a The correlation of the estimated TMB with WES-TMB using the Rizvi data (n = 34). b Estimated TMB in tumors from patients with DCB (n = 14) or with NDB (n = 17; Mann-Whitney, p = 0.0047). c PFS in tumors with estimated TMB-high (n = 12) compared to tumors with TMB-low (n = 22) in patients in the Rizvi cohort (HR 0.39, 95% CI 0.16 to 0.86, log-rank p = 0.0018). d The correlation of estimated TMB with WES-TMB using the late-stage NSCLC patient cohort (n = 73). e Estimated TMB in tumors from patients with DCB (n = 34) or with NDB (n = 39; Mann-Whitney, p = 0.0133). f PFS in tumors with estimated TMB-high (n = 21) compared to tumors with TMB-low (n = 52) in patients in the late-stage NSCLC patient cohort (HR 0.40, 95% CI 0.26 to 0.94, log-rank p = 0.0479)