Severe nausea and vomiting in pregnancy: psychiatric and cognitive problems and brain structure in children

Table 3 Incidence rate and hazard ratio of specific psychiatric disorders in offspring born during 1995–2012 in Denmark relating to maternal hyperemesis gravidarum

	No. of cases, N	Incidence rate, rate per 1000 person-years	Model 1, HR (95% CI)	Model 2, HR (95% CI)
Behavioral and emotional disorders*
No HG	41,869	3.07	Ref	Ref
Maternal HG	595	3.67	1.27 (1.17–1.38)	1.20 (1.10–1.30)
Attention-deficit/hyperactivity disorders
No HG	32,177	2.57	Ref	Ref
Maternal HG	437	2.85	1.23 (1.12–1.35)	1.16 (1.06–1.28)
Conduct disorders/oppositional defiant disorders
No HG	2024	0.15	Ref	Ref
Maternal HG	29	0.18	1.31 (0.91–1.89)	1.06 (1.71–1.57)
Emotional disorders
No HG	2884	0.21	Ref	Ref
Maternal HG	44	0.27	1.34 (1.00–1.81)	1.33 (0.98–1.89)
Pervasive developmental disorders
No HG	17,478	1.31
Maternal HG	232	1.46	1.23 (1.08–1.40)	1.19 (1.05–1.36)
Childhood autism
No HG	6877	0.50	Ref	Ref
Maternal HG	100	0.61	1.32 (1.08–1.61)	1.19 (0.97–1.45)
Developmental disorders^#
No HG	3362	0.24	Ref	Ref
Maternal HG	55	0.33	1.43 (1.10–1.86)	1.33 (1.02–1.75)

HG hyperemesis gravidarum, HR Hazard ratio, Model 1 children’s age at time scale, Model 2 children’s age at time scale, sex, year of birth, parity, parental age at birth, maternal education level, maternal country of origin, maternal cohabitation, and parental psychiatry disorders
*Behavioral and emotional disorders with onset usually occurring in childhood and adolescence
^#Developmental disorders including language, learning, and motor skills disorders

ISSN: 1741-7015