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Table 3 Incidence rate and hazard ratio of specific psychiatric disorders in offspring born during 1995–2012 in Denmark relating to maternal hyperemesis gravidarum

From: Severe nausea and vomiting in pregnancy: psychiatric and cognitive problems and brain structure in children

  No. of cases, N Incidence rate, rate per 1000 person-years Model 1, HR (95% CI) Model 2, HR (95% CI)
Behavioral and emotional disorders*
 No HG 41,869 3.07 Ref Ref
 Maternal HG 595 3.67 1.27 (1.17–1.38) 1.20 (1.10–1.30)
Attention-deficit/hyperactivity disorders
 No HG 32,177 2.57 Ref Ref
 Maternal HG 437 2.85 1.23 (1.12–1.35) 1.16 (1.06–1.28)
Conduct disorders/oppositional defiant disorders
 No HG 2024 0.15 Ref Ref
 Maternal HG 29 0.18 1.31 (0.91–1.89) 1.06 (1.71–1.57)
Emotional disorders
 No HG 2884 0.21 Ref Ref
 Maternal HG 44 0.27 1.34 (1.00–1.81) 1.33 (0.98–1.89)
Pervasive developmental disorders
 No HG 17,478 1.31   
 Maternal HG 232 1.46 1.23 (1.08–1.40) 1.19 (1.05–1.36)
Childhood autism
 No HG 6877 0.50 Ref Ref
 Maternal HG 100 0.61 1.32 (1.08–1.61) 1.19 (0.97–1.45)
Developmental disorders#
 No HG 3362 0.24 Ref Ref
 Maternal HG 55 0.33 1.43 (1.10–1.86) 1.33 (1.02–1.75)
  1. HG hyperemesis gravidarum, HR Hazard ratio, Model 1 children’s age at time scale, Model 2 children’s age at time scale, sex, year of birth, parity, parental age at birth, maternal education level, maternal country of origin, maternal cohabitation, and parental psychiatry disorders
  2. *Behavioral and emotional disorders with onset usually occurring in childhood and adolescence
  3. #Developmental disorders including language, learning, and motor skills disorders