TY - JOUR AU - Gunasekera, Kenneth S. AU - Zelner, Jon AU - Becerra, Mercedes C. AU - Contreras, Carmen AU - Franke, Molly F. AU - Lecca, Leonid AU - Murray, Megan B. AU - Warren, Joshua L. AU - Cohen, Ted PY - 2020 DA - 2020/09/02 TI - Children as sentinels of tuberculosis transmission: disease mapping of programmatic data JO - BMC Medicine SP - 234 VL - 18 IS - 1 AB - Identifying hotspots of tuberculosis transmission can inform spatially targeted active case-finding interventions. While national tuberculosis programs maintain notification registers which represent a potential source of data to investigate transmission patterns, high local tuberculosis incidence may not provide a reliable signal for transmission because the population distribution of covariates affecting susceptibility and disease progression may confound the relationship between tuberculosis incidence and transmission. Child cases of tuberculosis and other endemic infectious disease have been observed to provide a signal of their transmission intensity. We assessed whether local overrepresentation of child cases in tuberculosis notification data corresponds to areas where recent transmission events are concentrated. SN - 1741-7015 UR - https://doi.org/10.1186/s12916-020-01702-x DO - 10.1186/s12916-020-01702-x ID - Gunasekera2020 ER -