Table 1 Baseline characteristics of colorectal cancer cases and their matched controls by sex in the EPIC nested case-control study
Parameters | Men | Women | ||||
|---|---|---|---|---|---|---|
Case | Control | P | Case | Control | P | |
N | 658 | 658 | 728 | 728 | ||
Age at blood collection (years) | 58.6 (7.1) | 58.5 (7.1) | 0.9 | 58.1 (7.7) | 58.0 (7.7) | 0.9 |
Follow-up from blood collection (years) | 4.3 (2.5) | 4.3 (2.5) | ||||
Weight (kg) | 82.5 (12.1) | 80.4 (11.1) | 0.001 | 68.5 (12.4) | 66.8 (10.8) | 0.007 |
Height (cm) | 173.8 (6.8) | 173.4 (6.8) | 0.3 | 161.5 (6.5) | 160.8 (6.5) | 0.03 |
BMI (kg/m2) | 27.3 (3.8) | 26.7 (3.3) | 0.01 | 26.3 (4.7) | 25.9 (4.2) | 0.08 |
UCB (μmol/L) | 4.3 (2.6) | 4.0 (2.2) | 0.02 | 3.2 (1.8) | 3.4 (1.9) | 0.08 |
Frequency of main SNP (rs6431625) (n, %) | 0.1 | 0.2 | ||||
TT genotype (wild-type) | 163 (36) | 147 (41) | 219 (39) | 159 (35) | ||
TC genotype | 216 (48) | 160 (45) | 258 (46) | 218 (48) | ||
CC genotype | 75 (17) | 50 (14) | 83 (15) | 74 (16) | ||
Smoking status (n, %) | 0.2 | > 0.9 | ||||
Never | 156 (24) | 185 (28) | 426 (59) | 428 (59) | ||
Former | 310 (47) | 278 (42) | 160 (22) | 159 (22) | ||
Current | 180 (27) | 184 (28) | 138 (19) | 137 (19) | ||
Physical activity (n, %)† | 0.3 | 0.1 | ||||
Inactive | 157 (24) | 155 (24) | 207 (28) | 170 (23) | ||
Moderately inactive | 191 (29) | 184 (28) | 248 (34) | 269 (37) | ||
Moderately active | 159 (24) | 137 (21) | 154 (21) | 144 (20) | ||
Active | 143 (22) | 169 (26) | 116 (16) | 140 (19) | ||
Education (n, %)‡ | 0.1 | 0.9 | ||||
None | 39 (6) | 39 (6) | 43 (6) | 40 (5) | ||
Primary school completed | 227 (35) | 241 (37) | 238 (33) | 258 (35) | ||
Technical/professional school | 154 (23) | 177 (27) | 170 (23) | 166 (23) | ||
Secondary school | 84 (13) | 54 (8) | 141 (19) | 135 (19) | ||
Longer education (incl. university deg.) | 139 (21) | 131 (20) | 104 (14) | 111 (15) | ||
Unknown | 9 (1) | 12 (2) | 27 (4) | 15 (2) | ||
Menopause stage (n, %) | 0.6 | |||||
Pre-menopausal | 85 (12) | 90 (12) | ||||
Post-menopausal | 507 (70) | 515 (71) | ||||
Peri-menopausal | 98 (13) | 95 (13) | ||||
Surgical postmen (bilateral ovariectomy) | 38 (5) | 28 (4) | ||||
Ever use of HT (n, %) | 0.8 | |||||
No | 533 (73) | 526 (72) | ||||
Yes | 165 (23) | 174 (24) | ||||
Daily dietary intake, median (5th, 95th percentile) | ||||||
Energy (kcal) | 2286 (1383, 3558) | 2278 (1410, 3488) | 0.8 | 1870 (1093, 2906) | 1860 (1191, 2850) | 0.7 |
Alcohol (g) | 15 (0, 80) | 13 (0, 71) | 0.04 | 3 (0, 33) | 4 (0, 33) | 0.6 |
Red meat (g) | 51 (8, 145) | 49 (7, 135) | 0.4 | 38 (4, 105) | 40 (3, 105) | 0.9 |
Processed meat (g) | 34 (4, 111) | 32 (2, 111) | 0.1 | 21 (1, 71) | 20 (1,68) | 0.7 |
Fiber (g) | 23 (12, 38) | 23 (12, 40) | 0.2 | 21 (12, 35) | 22 (12, 34) | 0.1 |
Dairy products (g) | 257 (36, 765) | 282 (43, 767) | 0.1 | 299 (50, 801) | 324 (63, 813) | 0.02 |
Country (n, %) | > 0.9 | > 0.9 | ||||
France | 40 (5) | 40 (5) | ||||
Italy | 77 (12) | 77 (12) | 108 (15) | 108 (15) | ||
Spain | 86 (13) | 86 (13) | 79 (11) | 79 (11) | ||
UK | 123 (19) | 123 (19) | 125 (17) | 125 (17) | ||
The Netherlands | 23 (3) | 23 (3) | 147 (20) | 147 (20) | ||
Greece | 21 (3) | 21 (3) | 19 (3) | 19 (3) | ||
Germany | 120 (18) | 120 (18) | 64 (9) | 64 (9) | ||
Sweden | 44 (7) | 44 (7) | 30 (4) | 30 (4) | ||
Denmark | 164 (25) | 164 (25) | 105 (14) | 105 (14) | ||
Norway | 11 (2) | 11 (2) | ||||
Fasting status (n, %) | > 0.9 | > 0.9 | ||||
No | 324 (50) | 324 (50) | 361 (51) | 360 (51) | ||
Inbetween | 141 (22) | 140 (22) | 139 (19) | 139 (19) | ||
Yes | 185 (28) | 185 (28) | 215 (30) | 215 (30) | ||