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Table 2 Incremental cost-effectiveness of the lifestyle intervention versus control group over 2 years

From: Cost-effectiveness of a lifestyle intervention in high-risk individuals for diabetes in a low- and middle-income setting: Trial-based analysis of the Kerala Diabetes Prevention Program

 

Cost per diabetes case prevented

Cost per QALY gained

Health system perspective

Societal perspective

Health system perspective

Societal perspective

Base-case analysis

 Without discounting

95.2

295.1

50.0

155.0

 With discounting (3% per annum)

95.1

292.5

49.0

150.8

Sensitivity analyses

 Cost of group sessions only

  10% increase

157.1

357.0

82.5

187.5

  20% increase

219.0

414.1

115.0

217.5

  30% increase

276.1

476.0

145.0

250.0

  10% decrease

38.1

238.0

20.0

125.0

  20% decrease

Dominated*

176.1

Dominated*

92.5

  30% decrease

Dominated*

114.2

Dominated*

60.0

 Intervention effectiveness only

  10% increase

87.0

269.7

45.5

140.9

  20% increase

80.0

248.0

41.7

129.2

  30% increase

74.0

229.4

38.5

119.2

  10% decrease

105.2

326.1

55.6

172.2

  20% decrease

117.6

364.6

62.5

193.8

  30% decrease

133.4

413.5

71.4

221.4

 Both cost of group sessions and intervention effectiveness

  10% increase

143.6

326.3

75.0

170.5

  20% increase

184.0

348.0

95.8

181.3

  30% increase

214.6

370.0

111.5

192.3

  10% decrease

42.1

263.0

22.2

138.9

  20% decrease

Dominated*

217.6

Dominated*

115.6

  30% decrease

Dominated*

160.1

Dominated*

85.7

 Discounting

  5% per annum

116.8

292.5

60.5

151.5

  10% per annum

169.4

292.7

88.4

152.7

 MI analysis

  Lifestyle intervention vs. control group

99.2

302.1

56.0

157.5

  1. QALY quality-adjusted life year, MI multiple imputation
  2. *Lifestyle intervention was less costly and more effective than the control group