Pre-specify before recruitment | Pre-specify the analysis strategy before recruitment to the trial begins. |
Single analysis strategy | Specify a single primary analysis strategy. |
Plan each aspect | Each aspect of the planned analysis should be covered, including analysis population, statistical model, covariates, and handling of missing data. |
Enough detail | Provide sufficient detail to allow a third party to independently perform the analysis (ideally through statistical code). |
Choices made deterministically | For adaptive analysis strategies which use the trial data to inform some aspect of the analysis, use deterministic decision rules that prevent analysis choices being driven by results. |