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Table 3 Take-home ideas about non-alcoholic fatty liver disease related to psychiatric illnesses

From: Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches

NAFLD = strongly related to MetS
NASH = steatosis + inflammation
NAFLD and NASH are core elements driving metabolic diseases that are often neglected.
NASH implies a high risk of progression to cirrhosis and hepatocellular carcinoma.
Psychiatric conditions and NAFLD are bidirectionally related.
Rates of NAFLD and NASH in psychiatric patients are high.
60% of the excess mortality in psychiatric patients is due to physical comorbidities.
Some common factors between psychiatric and metabolic disorders are:
genetic (adiponutrin, microRNA), mitochondrial and oxidative stress dysregulations, dysbiosis, psychological factors and lifestyle (diet and exercise).
Possible treatments include changes in lifestyle, insulin sensitizers or statins.
Diagnosis involves imaging and histology; therefore, widespread screening is difficult.
Some questionnaires and biological markers are being investigated in order to make diagnosis easier and less invasive.
Being aware of covert hepatic disorders and achieving an early diagnosis and adequate treatment could potentially benefit psychiatric patients in terms of prognosis and quality of life.
  1. Abbreviations: NAFLD non-alcoholic fatty liver disease, MetS metabolic syndrome, NASH non-alcoholic steatohepatitis