NAFLD = strongly related to MetS|
NASH = steatosis + inflammation
NAFLD and NASH are core elements driving metabolic diseases that are often neglected.|
NASH implies a high risk of progression to cirrhosis and hepatocellular carcinoma.
Psychiatric conditions and NAFLD are bidirectionally related.|
Rates of NAFLD and NASH in psychiatric patients are high.
60% of the excess mortality in psychiatric patients is due to physical comorbidities.
Some common factors between psychiatric and metabolic disorders are:|
genetic (adiponutrin, microRNA), mitochondrial and oxidative stress dysregulations, dysbiosis, psychological factors and lifestyle (diet and exercise).
|Possible treatments include changes in lifestyle, insulin sensitizers or statins.|
Diagnosis involves imaging and histology; therefore, widespread screening is difficult.|
Some questionnaires and biological markers are being investigated in order to make diagnosis easier and less invasive.
|Being aware of covert hepatic disorders and achieving an early diagnosis and adequate treatment could potentially benefit psychiatric patients in terms of prognosis and quality of life.|