Input parameter | Base case analyses | One-way sensitivity analysis range | Probabilistic sensitivity analysis distribution | Source |
---|---|---|---|---|
Endoscopy | ||||
 Sensitivity | 0.8860000 | 0.6982–0.976 | Beta | [56] |
 Specificity | 0.8510000 | 0.8430–0.859 | Beta | [56] |
 Complicationsa | 0.0000195 | Fixed | Beta | [53] |
 Death | 0.0000011 | Fixed | Beta | [53] |
Endoscopic submucosal dissection | ||||
 Complete resectionb | 0.9000000 | 0.8–1.0 | Beta | [54] |
 Complicationsc | 0.0241927 | Fixed | Beta | [53] |
 Death | 0.0001599 | Fixed | Beta | [53] |
 Recurrence | 0.0140000 | Fixed | Beta | [55] |
Surgery (gastrectomy) | ||||
 Complete resection | 1.0000000 | Fixed | Fixed | |
 Complications | 0.0615385 | Fixed | Beta | [59] |
 Death | 0.0043956 | Fixed | Beta | |
 Recurrence | 0.0040000 | Fixed | Beta | [55] |
Quality of life/utilities | ||||
 Endoscopy without complication | − 1 day | Fixed | Fixed | [61] |
 Endoscopy with complication | − 1 weeks | Fixed | Fixed | [61] |
 Surgery without complication | − 2 week | Fixed | Fixed | [61] |
 Surgery with complication | − 1 month | Fixed | Fixed | [61] |
 Gastric cancer |  | Fixed | Fixed |  |
  Local | 0.773 | Fixed | Fixed | [62] |
  Regional | 0.590 | Fixed | Fixed | [62] |
  Distant | 0.404 | Fixed | Fixed | [62] |
Discounting | ||||
 Costs | 3% | 3.5–6% | Fixed | [63] |
 Quality-adjusted life-years | 3% | 0–1.5% | Fixed | [63] |
Cost (US$)d | ||||
 Direct | ||||
  Endoscopy | 127 | 90–160 | Gamma | [64] |
  ESD | 1731 | 1400–2000 | Gamma | [65] |
  Endoscopy/ESD complication | 380 | 250–450 | Gamma | [65] |
  Endoscopy/ESD complication | 852 | 700–1000 | Gamma | [65] |
  Local cancer, first year | 11,110 | 8000–14,000 | Gamma | [64] |
  Local cancer, subsequent years | 1544 | Fixed | Gamma | [64] |
  Regional cancer, first year | 20,645 | 15,000–25,000 | Gamma | [64] |
  Regional cancer, subsequent years | 3171 | Fixed | Gamma | [64] |
  Distal cancer, first year | 29,610 | 25,000–35,000 | Gamma | [64] |
  Distal cancer, subsequent years | 5655 | Fixed | Gamma | [64] |
  Terminal care year in each stage | 51,497 | Fixed | Gamma | [64] |
 Indirect | ||||
  Endoscopy, hours | 8 | Fixed | Fixed | [66] |
  ESD, hours | 56 | Fixed | Fixed | [65] |
  Surgery, hours | 136 | Fixed | Fixed | [65] |
  First year of cancer treatment, hours | 351 | Fixed | Fixed | [67] |
  Subsequent years of cancer treatment, hours | 48 | Fixed | Fixed | [67] |
  Final year of cancer treatment, hours | 512 | Fixed | Fixed | [67] |