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Table 1 Key input parameters included in our analysis

From: Effect and cost-effectiveness of national gastric cancer screening in Japan: a microsimulation modeling study

Input parameter

Base case analyses

One-way sensitivity analysis range

Probabilistic sensitivity analysis distribution

Source

Endoscopy

 Sensitivity

0.8860000

0.6982–0.976

Beta

[56]

 Specificity

0.8510000

0.8430–0.859

Beta

[56]

 Complicationsa

0.0000195

Fixed

Beta

[53]

 Death

0.0000011

Fixed

Beta

[53]

Endoscopic submucosal dissection

 Complete resectionb

0.9000000

0.8–1.0

Beta

[54]

 Complicationsc

0.0241927

Fixed

Beta

[53]

 Death

0.0001599

Fixed

Beta

[53]

 Recurrence

0.0140000

Fixed

Beta

[55]

Surgery (gastrectomy)

 Complete resection

1.0000000

Fixed

Fixed

[57, 58]

 Complications

0.0615385

Fixed

Beta

[59]

 Death

0.0043956

Fixed

Beta

[58, 60]

 Recurrence

0.0040000

Fixed

Beta

[55]

Quality of life/utilities

 Endoscopy without complication

− 1 day

Fixed

Fixed

[61]

 Endoscopy with complication

− 1 weeks

Fixed

Fixed

[61]

 Surgery without complication

− 2 week

Fixed

Fixed

[61]

 Surgery with complication

− 1 month

Fixed

Fixed

[61]

 Gastric cancer

 

Fixed

Fixed

 

  Local

0.773

Fixed

Fixed

[62]

  Regional

0.590

Fixed

Fixed

[62]

  Distant

0.404

Fixed

Fixed

[62]

Discounting

 Costs

3%

3.5–6%

Fixed

[63]

 Quality-adjusted life-years

3%

0–1.5%

Fixed

[63]

Cost (US$)d

 Direct

  Endoscopy

127

90–160

Gamma

[64]

  ESD

1731

1400–2000

Gamma

[65]

  Endoscopy/ESD complication

380

250–450

Gamma

[65]

  Endoscopy/ESD complication

852

700–1000

Gamma

[65]

  Local cancer, first year

11,110

8000–14,000

Gamma

[64]

  Local cancer, subsequent years

1544

Fixed

Gamma

[64]

  Regional cancer, first year

20,645

15,000–25,000

Gamma

[64]

  Regional cancer, subsequent years

3171

Fixed

Gamma

[64]

  Distal cancer, first year

29,610

25,000–35,000

Gamma

[64]

  Distal cancer, subsequent years

5655

Fixed

Gamma

[64]

  Terminal care year in each stage

51,497

Fixed

Gamma

[64]

 Indirect

  Endoscopy, hours

8

Fixed

Fixed

[66]

  ESD, hours

56

Fixed

Fixed

[65]

  Surgery, hours

136

Fixed

Fixed

[65]

  First year of cancer treatment, hours

351

Fixed

Fixed

[67]

  Subsequent years of cancer treatment, hours

48

Fixed

Fixed

[67]

  Final year of cancer treatment, hours

512

Fixed

Fixed

[67]

  1. ESD endoscopic submucosal dissection. aEndoscopic-related screening and diagnostic complications included bleeding and perforation. bComplete resection was defined as resection with tumor-free lateral and vertical margins, without submucosal invasion and lymphovascular invasion. cComplication of endoscopic submucosal dissection included bleeding and perforation. dCosts are presented in 2015 US dollars using an exchange rate of 121. We assumed that the median hourly wage of US$16.75 in 2015 was equivalent to the value of patient time [68]