Maternal lipid profile in early pregnancy is associated with foetal growth and the risk of a child born large-for-gestational age: a population-based prospective cohort study

Adank, Maria C.; Benschop, Laura; Kors, Alet W.; Peterbroers, Kelly R.; Smak Gregoor, Anna M.; Mulder, Monique T.; Schalekamp-Timmermans, Sarah; Roeters Van Lennep, Jeanine E.; Steegers, Eric A. P.

doi:10.1186/s12916-020-01730-7

Table 3 Associations of maternal lipid levels in early pregnancy with birth anthropometrics

From: Maternal lipid profile in early pregnancy is associated with foetal growth and the risk of a child born large-for-gestational age: a population-based prospective cohort study

	Head circumference (mm) β (95% CI) n = 3110	P value	Birth length (mm) β (95% CI) n = 3641	P value	Birth weight (g) β (95% CI) n = 5666	P value
Total cholesterol, SDS
Basic model	0.2 (− 0.4 to 0.8)	0.44	0.1 (− 0.6 to 0.9)	0.73	9.2 (− 2.5 to 20.9)	0.12
BMI model	0.1 (− 0.4 to 0.7)	0.65	− 0.1 (− 0.8 to 0.7)	0.89	3.2 (− 8.4 to 14.8)	0.59
Glucose model	0.1 (− 0.4 to 0.7)	0.63	− 0.0 (− 0.8 to 0.7)	0.90	3.6 (− 8.1 to 15.2)	0.55
Triglycerides, SDS
Basic model	0.8 (0.2 to 1.3)	0.01	0.6 (− 0.2 to 1.3)	0.13	29.6 (17.9 to 41.3)	< 0.001
BMI model	0.6 (0.1 to 1.2)	0.03	0.3 (− 0.5 to 1.0)	0.48	19.5 (7.6 to 31.3)	0.001
Glucose model	0.6 (0.04 to 1.2)	0.04	0.2 (− 0.5 to 1.0)	0.53	18.4 (6.5 to 30.3)	0.002
LDL-c, SDS
Basic model	0.2 (−0.4 to 0.8)	0.51	0.2 (− 0.5 to 1.0)	0.51	10.2 (− 1.3 to 21.7)	0.08
BMI model	0.1 (− 0.5 to 0.7)	0.79	0.0 (− 0.7 to 0.7)	0.96	2.9 (− 8.5 to 14.4)	0.62
Glucose model	0.1 (− 0.5 to 0.7)	0.78	0.0 (− 0.7 to 0.7)	0.95	3.2 (− 8.3 to 14.7)	0.58
HDL-c, SDS
Basic model	− 0.4 (− 1.0 to 0.2)	0.15	− 0.7 (− 1.4 to 0.1)	0.07	−20.1 (−31.7 to − 8.5)	0.001
BMI model	− 0.3 (− 0.9 to 0.3)	0.27	− 0.4 (− 1.2 to 0.3)	0.22	−12.7 (− 24.3 to − 1.1)	0.03
Glucose model	− 0.3 (− 0.9 to 0.3)	0.32	− 0.4 (− 1.2 to 0.3)	0.25	−11.6 (− 23.2 to 0.1)	0.05
Remnant cholesterol, SDS
Basic model	0.8 (0.2 to 1.4)	0.01	0.6 (− 0.1 to 1.3)	0.11	30.0 (18.3 to 41.8)	< 0.001
BMI model	0.7 (0.1 to 1.3)	0.02	0.3 (− 0.4 to 1.0)	0.44	19.8 (7.9 to 31.6)	0.001
Glucose model	0.7 (0.1 to 1.2)	0.03	0.3 (− 0.5 to 1.0)	0.48	18.7 (6.8 to 30.6)	0.002
Non-HDL-c, SDS
Basic model	0.4 (− 0.2 to 1.0)	0.18	0.4 (− 0.3 to 1.1)	0.27	17.7 (6.1 to 29.3)	0.003
BMI model	0.3 (− 0.3 to 0.8)	0.38	0.1 (− 0.6 to 0.9)	0.74	8.4 (− 3.3 to 20.0)	0.16
Glucose model	0.3 (− 0.3 to 0.8)	0.39	0.1 (− 0.6 to 0.8)	0.74	8.2 (− 3.4 to 19.9)	0.17

Abbreviations: CI confidence interval, SDS SD scores, LDL-c low-density lipoprotein cholesterol, HDL-c high-density lipoprotein cholesterol. Values are beta’s (95% CI) derived from multiple linear regression analyses. Basic model: adjusted for maternal age, gestational age at blood sampling, ethnicity, educational level, parity, smoking, folic acid supplementation and gestational age at measurement. BMI model: basic model additionally adjusted for pre-pregnancy BMI. Glucose model: BMI model additionally adjusted for glucose levels in early pregnancy

Back to article page

ISSN: 1741-7015

Contact us

Submission enquiries: bmcmedicineeditorial@biomedcentral.com
General enquiries: info@biomedcentral.com

BMC Medicine

Contact us