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Table 4 Associations of maternal lipid profile in early pregnancy with birth outcomes

From: Maternal lipid profile in early pregnancy is associated with foetal growth and the risk of a child born large-for-gestational age: a population-based prospective cohort study

 

AGA

n = 4526

SGA

OR (95% CI)

n = 564

P value

LGA

OR (95% CI)

n = 565

P value

Total cholesterol, SDS

 Basic model

Reference

0.94 (0.85 to 1.03)

0.16

1.00 (0.92 to 1.10)

0.94

 BMI model

Reference

0.96 (0.87 to 1.05)

0.33

0.97 (0.88 to 1.06)

0.51

 Glucose model

Reference

0.95 (0.87 to 1.05)

0.32

0.97 (0.87 to 1.07)

0.57

Triglycerides, SDS

 Basic model

Reference

0.91 (0.83 to 1.00)

0.04

1.18 (1.07 to 1.29)

0.001

 BMI model

Reference

0.94 (0.85 to 1.03)

0.17

1.11 (1.01 to 1.22)

0.04

 Glucose model

Reference

0.94 (0.85 to 1.03)

0.19

1.09 (0.99 to 1.20)

0.08

LDL-c, SDS

 Basic model

Reference

0.95 (0.87 to 1.04)

0.28

1.01 (0.92 to 1.10)

0.91

 BMI model

Reference

0.98 (0.89 to 1.07)

0.59

0.96 (0.88 to 1.06)

0.43

 Glucose model

Reference

0.98 (0.89 to 1.07)

0.59

0.97 (0.88 to 1.06)

0.47

HDL-c, SDS

 Basic model

Reference

1.01 (0.92 to 1.10)

0.91

0.88 (0.81 to 0.97)

0.01

 BMI model

Reference

0.98 (0.90 to 1.07)

0.67

0.92 (0.84 to 1.01)

0.09

 Glucose model

Reference

0.98 (0.89 to 1.07)

0.62

0.93 (0.85 to 1.03)

0.16

Remnant cholesterol, SDS

 Basic model

Reference

0.91 (0.83 to 1.00)

0.05

1.18 (1.08 to 1.30)

< 0.001

 BMI model

Reference

0.94 (0.86 to 1.03)

0.20

1.11 (1.01 to 1.23)

0.03

 Glucose model

Reference

0.94 (0.86 to 1.04)

0.23

1.10 (1.00 to 1.21)

0.06

Non-HDL-c, SDS

 Basic model

Reference

0.93 (0.85 to 1.02)

0.13

1.05 (0.96 to 1.15)

0.27

 BMI model

Reference

0.96 (0.88 to 1.06)

0.40

1.00 (0.91 to 1.09)

0.95

 Glucose model

Reference

0.96 (0.88 to 1.06)

0.41

1.00 (0.91 to 1.09)

0.92

  1. Abbreviations: OR odds ratio, CI confidence interval, SDS SD scores, AGA average-for-gestational age, SGA small-for-gestational age, LGA large-for-gestational age, LDL-c low-density lipoprotein cholesterol, HDL-c high-density lipoprotein cholesterol. Values are odds ratio’s (95% CI) derived from multiple logistic regression analyses. Basic model: adjusted for maternal age, gestational age at blood sampling, ethnicity, educational level, parity, smoking and folic acid supplementation. BMI model: basic model additionally adjusted for pre-pregnancy BMI. Glucose model: BMI model additionally adjusted for glucose levels in early pregnancy
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BMC Medicine

ISSN: 1741-7015

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