Modulea | Nmetabolite | Top hub metaboliteb | mPTD + preeclampsia | mPTD only | sPTD |
---|
Beta ± SEc | P | Beta ± SEc | P | Beta ± SEc | P |
---|
Blue | 54 | C44:1 TAG | 0.000 ± 0.003 | 0.98 | − 0.011 ± 0.004 | 0.004* | − 0.003 ± 0.002 | 0.10 |
Yellow | 38 | C16:0 CE or C36:2 DAGd | 0.016 ± 0.003 | 7.8 × 10–7* | − 0.001 ± 0.004 | 0.86 | − 0.004 ± 0.002 | 0.06 |
Pink | 26 | C18:1 LPC | 0.009 ± 0.003 | 0.007 | 0.005 ± 0.004 | 0.24 | 0.005 ± 0.002 | 0.03 |
Red | 36 | C32:2 PC | 0.001 ± 0.003 | 0.76 | − 0.008 ± 0.004 | 0.03 | − 0.002 ± 0.002 | 0.30 |
Turquoise | 63 | C16:0 sphingomyelin | − 0.001 ± 0.003 | 0.74 | 0.001 ± 0.004 | 0.71 | 0.000 ± 0.002 | 0.85 |
Black | 34 | C14:1 carnitine | 0.015 ± 0.003 | 1.6 × 10–5* | 0.009 ± 0.004 | 0.02 | 0.002 ± 0.002 | 0.33 |
Brown | 41 | Valine | 0.003 ± 0.003 | 0.38 | 0.001 ± 0.004 | 0.77 | 0.001 ± 0.002 | 0.66 |
Green | 37 | Pseudouridine | 0.011 ± 0.003 | 7.0 × 10–4* | 0.002 ± 0.004 | 0.54 | − 0.006 ± 0.002 | 0.003* |
- mPTD medically indicated PTD, CE cholesteryl ester, DAG diacylglycerol, LPC lysophosphatidylcholine, PC phosphatidylcholine, TAG triacylglycerol
- aThe WGCNA analysis was conducted on 1330 samples using the “unsigned” network, where the highly correlated (either positive or negative) metabolites were grouped into the same module
- bThe top hub metabolite was defined as the one with the highest mean correlation with the other metabolites in the same module
- cAdjusted for maternal age at delivery, maternal ethnicity/race, maternal birthplace, pregestational BMI category, pregestational diabetes, chronic hypertension, marital status, highest education level, parity, smoking during pregnancy, illicit drug use, lifetime stress, and fetal sex
- dC16:0 CE is negatively correlated with the “yellow” module score while C36:2 DAG is positively correlated with the “yellow” module score
- *Significant after Bonferroni corrections for multiple testing on 8 metabolite modules