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Fig. 3 | BMC Medicine

Fig. 3

From: Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway

Fig. 3

Associations were coupled between abuse-BMI and abuse-brain. a Smaller volume of the FPC was associated with deeper negative association between CA and the FPC volume (CA-FPC assoc) across both male (gray dots) and female (blue dots) subjects at the 6 data collection sites in the IMAGEN cohort. The FPC volume shown here was the ratio between the raw FPC volume and the TIV. b The partial correlation coefficient between CA and BMI was associated with the partial correlation coefficient between CA and the FPC volume in male subjects across the 6 data collection sites in the IMAGEN study and the UK Biobank sample. c Significant cortical connectivity of the hypothalamus using 7-T dMRI data from HCP. The fiber number was normalized as a percentage of the connections tracked between one brain region and one subdivision of the hypothalamus among all its tracked connections. The connections survived the FDR correction were reported. The upper plot shows the median of the fiber number, the middle plot marks the significant connectivity in black, and the lower plot shows the significant differences in connectivity between lateral and medial hypothalamus. The abbreviations of the cortical parcels are defined by the HCP-MMP atlas. The hypothalamus was divided into 8 subdivisions along the anterior-posterior and the medial-lateral lines. L, left; R, right; AL, anterior lateral; AM, anterior medial; PL, posterior lateral; PM, posterior medial. d One exemplar of the fiber tracking results. Only the fibers ending in the hypothalamus (marked in red, defined by the CIT168 atlas) were shown. The surface views of the white matter connectivity of the lateral (e) and the medial (f) hypothalamus. The maximum of the connectivity (normalized fiber number, %) between the anterior and posterior parts of either the lateral or the medial hypothalamus. FPC, frontopolar cortex; CA, childhood abuse; TIV, total intracranial volume; BMI, body mass index; HTH, hypothalamus

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