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Table 5 Univariate and multivariate Cox regression model associated with the SLC32A1/MSR1 gene signature

From: A machine learning analysis of a “normal-like” IDH-WT diffuse glioma transcriptomic subgroup associated with prolonged survival reveals novel immune and neurotransmitter-related actionable targets

Characteristics

Univariate Cox regression

Multivariate Cox regression

Beta

HRa (95% CIb for HR)

p value

Beta

HRa (95% CIb for HR)

p value

Age

0.034

1.035 (1.021–1.048)

6.75e−07

0.02

1.020 (1.004–1.037)

1.42e−02

Gender

 Female

Reference

     

 Male

0.325

1.384 (0.991–1.932)

5.65e−02

0.073

1.076 (0.756–1.531)

6.83e−01

Grade

 G2

Reference

     

 G3

0.883

2.419 (0.850–6.881)

9.77e−02

0.547

1.728 (0.576–5.187)

3.29e−01

 G4

1.75

5.752 (2.113–15.660)

6.18e−04

1.186

3.273 (1.045–10.250)

4.18e−02

EGFR

 Amplification

Reference

     

 WT

− 0.888

0.412 (0.223–0.761)

4.64e−03

− 0.337

0.714 (0.328–1.555)

3.96e−01

CDKN2A

 CDKN2A deletion

Reference

     

 CDKN2A WT

− 0.702

0.496 (0.332–0.741)

6.13e−04

− 1.691

0.184 (0.023–1.472)

1.11e−01

CDKN2B

 CDKN2B deletion

Reference

     

 CDKN2B WT

− 0.653

0.520 (0.350–0.774)

1.25e−03

1.276

3.584 (0.465–27.617)

2.21e−01

`Chr 7 gain/chr 10 loss

 `Chr 7 gain/chr 10 loss combined CNA

Reference

     

 `Chr 7 gain/chr 10 loss no combined CNA

− 0.381

0.683 (0.482–0.968)

3.20e−02

0.022

1.023 (0.682–1.533)

9.14e−01

SLC32A1/MSR1 signature

 SLC32A1_low–MSR1_low

− 0.172

0.842 (0.385–1.842)

6.67e−01

0.304

1.355 (0.568–3.233)

4.94e−01

 SLC32A1_medium–MSR1_low

− 0.91

0.403 (0.193–0.841)

1.55e−02

− 0.801

0.449 (0.203–0.991)

4.74e−02

 SLC32A1_high–MSR1_low

− 0.766

0.465 (0.283–0.762)

2.41e−03

0

1.000 (0.554–1.808)

9.99e−01

 SLC32A1_low–MSR1_high

0.136

1.145 (0.728–1.800)

5.57e−01

− 0.109

0.897 (0.552–1.456)

6.60e−01

 SLC32A1_medium–MSR1_high

− 0.149

0.862 (0.566–1.313)

4.89e−01

− 0.084

0.920 (0.584–1.448)

7.18e−01

  1. aHazard ratio
  2. bConfidence interval