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Table 6 Univariate and multivariate Cox regression model associated with the SYT5/C5AR1 gene signature

From: A machine learning analysis of a “normal-like” IDH-WT diffuse glioma transcriptomic subgroup associated with prolonged survival reveals novel immune and neurotransmitter-related actionable targets

Characteristics Univariate Cox regression Multivariate Cox regression
Beta HRa (95% CIb for HR) p value Beta HRa (95% CIb for HR) p value
Age 0.034 1.035 (1.021–1.048) 6.75e−07 0.022 1.023 (1.006–1.039) 5.90e−03
Gender
 Female Reference      
 Male 0.325 1.384 (0.991–1.932) 5.65e−02 0.165 1.179 (0.823–1.689) 3.69e−01
Grade
 G2 Reference      
 G3 0.883 2.419 (0.850–6.881) 9.77e−02 0.557 1.745 (0.587–5.189) 3.16e−01
 G4 1.75 5.752 (2.113–15.660) 6.18e−04 0.901 2.461 (0.820–7.389) 1.08e−01
EGFR
 Amplification Reference      
 WT − 0.888 0.412 (0.223–0.761) 4.64e−03 − 0.391 0.677 (0.314–1.459) 3.19e−01
CDKN2A
 CDKN2A deletion Reference      
 CDKN2A WT − 0.702 0.496 (0.332–0.741) 6.13e−04 − 1.903 0.149 (0.018–1.212) 7.51e−02
CDKN2B
 CDKN2B deletion Reference      
 CDKN2B WT − 0.653 0.520 (0.350–0.774) 1.25e−03 1.399 4.053 (0.511–32.157) 1.85e−01
`Chr 7 gain/chr 10 loss
 `Chr 7 gain/chr 10 loss combined CNA Reference      
 `Chr 7 gain/chr 10 loss no combined CNA − 0.381 0.683 (0.482–0.968) 3.20e−02 0.006 1.006 (0.673–1.502) 9.78e−01
SYT5/C5AR1 signature
 SYT5_low–C5AR1_low − 0.646 0.524 (0.250–1.100) 8.77e−02 − 0.536 0.585 (0.271–1.266) 1.73e−01
 SYT5_medium–C5AR1_low − 0.858 0.424 (0.250–0.718) 1.41e−03 − 0.836 0.434 (0.248–0.759) 3.42e−03
 SYT5_high–C5AR1_low − 0.668 0.513 (0.312–0.843) 8.47e−03 − 0.325 0.722 (0.397–1.313) 2.86e−01
 SYT5_low–C5AR1_high − 0.223 0.800 (0.453–1.414) 4.43e−01 − 0.437 0.646 (0.349–1.197) 1.65e−01
 SYT5_medium–C5AR1_high − 0.081 0.922 (0.600–1.418) 7.13e−01 − 0.211 0.810 (0.506–1.296) 3.79e−01
  1. aHazard ratio
  2. bConfidence interval