Table 6 Univariate and multivariate Cox regression model associated with the SYT5/C5AR1 gene signature

Age

0.034

1.035 (1.021–1.048)

6.75e−07

0.022

1.023 (1.006–1.039)

5.90e−03

 Female

Reference

 Male

0.325

1.384 (0.991–1.932)

5.65e−02

0.165

1.179 (0.823–1.689)

3.69e−01

 G2

Reference

 G3

0.883

2.419 (0.850–6.881)

9.77e−02

0.557

1.745 (0.587–5.189)

3.16e−01

 G4

1.75

5.752 (2.113–15.660)

6.18e−04

0.901

2.461 (0.820–7.389)

1.08e−01

 Amplification

Reference

 WT

− 0.888

0.412 (0.223–0.761)

4.64e−03

− 0.391

0.677 (0.314–1.459)

3.19e−01

 CDKN2A deletion

Reference

 CDKN2A WT

− 0.702

0.496 (0.332–0.741)

6.13e−04

− 1.903

0.149 (0.018–1.212)

7.51e−02

 CDKN2B deletion

Reference

 CDKN2B WT

− 0.653

0.520 (0.350–0.774)

1.25e−03

1.399

4.053 (0.511–32.157)

1.85e−01

 `Chr 7 gain/chr 10 loss combined CNA

Reference

 `Chr 7 gain/chr 10 loss no combined CNA

− 0.381

0.683 (0.482–0.968)

3.20e−02

0.006

1.006 (0.673–1.502)

9.78e−01

 SYT5_low–C5AR1_low

− 0.646

0.524 (0.250–1.100)

8.77e−02

− 0.536

0.585 (0.271–1.266)

1.73e−01

 SYT5_medium–C5AR1_low

− 0.858

0.424 (0.250–0.718)

1.41e−03

− 0.836

0.434 (0.248–0.759)

3.42e−03

 SYT5_high–C5AR1_low

− 0.668

0.513 (0.312–0.843)

8.47e−03

− 0.325

0.722 (0.397–1.313)

2.86e−01

 SYT5_low–C5AR1_high

− 0.223

0.800 (0.453–1.414)

4.43e−01

− 0.437

0.646 (0.349–1.197)

1.65e−01

 SYT5_medium–C5AR1_high

− 0.081

0.922 (0.600–1.418)

7.13e−01

− 0.211

0.810 (0.506–1.296)

3.79e−01