Fig. 1

The pretreatment gut microbiome of women who will gain weight following chemotherapy is different from the gut microbiome of women who will not gain weights. 16S rRNA sequencing was performed to characterize bacterial changes. a Principal coordinates analysis based on unweighted UniFrac distance matrix between women that will (red) and will not (blue) gain weight following chemotherapy treatment (p value = 0.012). b Alpha diversity comparison based on phylogenetic diversity (p value = 0.01). c Linear Discriminant Analysis (LDA) of the effect Size (LEfSe). d A single link hierarchical clustering based on an unweighted UniFrac distance matrix. K-nearest neighbor (KNN) classifier was used for classification. The colors in the heatmap represent beta diversity values. The blue and yellow bars on the right represent control and weight gain, respectively. The bar on the top represents different women. The lines in the dendrogram are colored based on the clusters. Black lines in the dendrogram represent samples different from the three main clusters. e The area under curve (AUC) for the ROC curve based on alpha diversity analysis