Trial | Whole sample | Participants aged ≥ 65 years | Number missing (%) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean frailty index | 99th centile | Frailty index categories (%) | Mean frailty index | 99th centile | Frailty index categories (%) | ||||||||
0–0.12 | 0.12–0.24 | 0.24–0.36 | > 0.36 | 0–0.12 | 0.12–0.24 | 0.24–0.36 | > 0.36 | ||||||
Type 2 diabetes | |||||||||||||
 NCT01106625 | 0.16 | 0.35 | 31.36 | 56.12 | 11.82 | 0.7 | 0.17 | 0.51 | 24.38 | 63.68 | 8.81 | 3.13 | 74 (16%) |
 NCT01106677 | 0.16 | 0.35 | 28.26 | 59.79 | 11.21 | 0.74 | 0.17 | 0.33 | 20.13 | 70.29 | 9.08 | 0.5 | 124 (10%) |
 NCT00734474 | 0.13 | 0.35 | 54.22 | 39.24 | 5.72 | 0.82 | 0.14 | 0.32 | 43.78 | 49.08 | 6.81 | 0.33 | 66 (5%) |
 NCT01064687 | 0.17 | 0.45 | 26.9 | 56.56 | 13.44 | 3.1 | 0.19 | 0.46 | 20.49 | 57.86 | 17.54 | 4.1 | 4 (0.4%) |
 NCT01075282 | 0.16 | 0.42 | 33.35 | 53.02 | 11.29 | 2.34 | 0.18 | 0.42 | 23.2 | 57.15 | 16.72 | 2.93 | 4 (0.5%) |
 NCT01191268 | 0.18 | 0.43 | 20.73 | 58.29 | 17.82 | 3.16 | 0.2 | 0.42 | 14.96 | 60.54 | 21.21 | 3.29 | 2 (0.2%) |
 NCT01624259 | 0.16 | 0.45 | 35.34 | 51.53 | 10.36 | 2.77 | 0.18 | 0.43 | 24.7 | 55.16 | 16.94 | 3.2 | 1 (0.2%) |
RA | |||||||||||||
 NCT00236028 | 0.26 | 0.41 | 2.62 | 37.05 | 53.73 | 6.6 | 0.27 | 0.41 | 1.15 | 28.08 | 61.5 | 9.27 | 12 (2%) |
 NCT00264537 | 0.28 | 0.44 | 1.14 | 25.99 | 58.83 | 14.05 | 0.31 | 0.46 | 0.16 | 15.63 | 63.43 | 20.78 | 4 (0.6%) |
 NCT00264550 | 0.27 | 0.45 | 2.03 | 34.71 | 51.37 | 11.89 | 0.28 | 0.41 | 3.58 | 24.91 | 57.11 | 14.41 | 2 (0.5%) |
 NCT00361335 | 0.28 | 0.45 | 1.49 | 29.24 | 55.43 | 13.85 | 0.29 | 0.46 | 0.73 | 26.31 | 56.99 | 15.96 | 1 (0.2%) |
 NCT00106535 | 0.22 | 0.4 | 11.57 | 46.97 | 37.19 | 4.27 | 0.24 | 0.4 | 9.73 | 39.92 | 44.71 | 5.64 | 4 (0.3%) |
 NCT01007435 | 0.2 | 0.4 | 18.92 | 47.79 | 29.95 | 3.35 | 0.21 | 0.41 | 15.89 | 46.55 | 32.81 | 4.75 | 9 (3%) |
 NCT01119859 | 0.24 | 0.44 | 8.5 | 43.27 | 39.88 | 8.36 | 0.25 | 0.48 | 7.07 | 40.41 | 40.3 | 12.22 | 3 (0.3%) |
 NCT01232569 | 0.22 | 0.4 | 10.32 | 49.31 | 36.44 | 3.93 | 0.23 | 0.4 | 7.59 | 47.37 | 41.24 | 3.8 | 0 (0%) |
COPD | |||||||||||||
 NCT01316900 | 0.18 | 0.35 | 24.62 | 55.68 | 18.9 | 0.8 | 0.17 | 0.35 | 25.83 | 57.28 | 16.3 | 0.58 | 33 (4%) |
 NCT01316913 | 0.18 | 0.35 | 22.04 | 55.71 | 21.56 | 0.69 | 0.18 | 0.35 | 24.64 | 55.33 | 19.38 | 0.65 | 19 (2%) |
 NCT01957163 | 0.17 | 0.37 | 27.13 | 55.71 | 15.74 | 1.42 | 0.17 | 0.36 | 28.32 | 56.89 | 13.79 | 1 | 0 (0%) |
 NCT02119286 | 0.16 | 0.35 | 30.74 | 53.91 | 14.67 | 0.68 | 0.16 | 0.33 | 30.75 | 56.81 | 12.1 | 0.34 | 2 (0.3%) |