Association between antipsychotic use and acute ischemic heart disease in women but not in men: a retrospective cohort study of over one million primary care patients

Table 2 Adjusted hazard ratios [95% confidence intervals] of acute ischemic heart disease

	Sex-specific models		Sex-combined model
	Men only	Women only	Men + women
*Antipsychotic prescription*	*0.95 [0.73, 1.23]*	1.32 [1.05, 1.67]*	1.19 [1.00, 1.41]*
*Men (women as referent)*			2.19 [2.10, 2.29]***
Age (in 10 years)	1.55 [1.51, 1.59]***	2.37 [2.30, 2.44]***	1.86 [0.55, 6.32]**
Antidepressant prescription	1.14 [0.94, 1.39]	1.15 [0.96, 1.37]	1.16 [1.01, 1.32]*
International Classification of Primary Care Diagnoses as baseline^a
Dementia	0.99 [0.47, 2.08]	0.54 [0.30, 0.99]*	0.78 [0.49, 1.23]
Tobacco abuse	1.55 [1.28, 1.88]***	3.16 [1.83, 5.46]***	1.68 [1.40, 2.01]***
Diabetes	1.29 [1.20, 1.38]***	1.62 [1.49, 1.76]***	1.43 [1.35, 1.50]***
Hypertension	1.60 [1.50, 1.70]***	1.50 [1.39, 1.63]***	1.55 [1.47, 1.62]***
Atrial fibrillation	1.20 [0.86, 1.67]	1.06 [0.72, 1.55]	1.16 [0.90, 1.49]
Stroke	1.31 [1.11, 1.55]**	1.49 [1.23, 1.82]***	1.37 [1.20, 1.55]***
Lipid disorder without any statin prescription^b	1.12 [1.01, 1.24]*	1.15 [1.03, 1.28]*	1.14 [1.06, 1.23]***
Statin prescription for those without lipid disorder^b	1.62 [1.46, 1.80]***	1.59 [1.38, 1.82]***	1.59 [1.47, 1.73]***
Lipid disorder with statin prescription^b	0.73 [0.61, 0.87]***	0.63 [0.50, 0.78]***	0.69 [0.60, 0.79]***

***P < 0.001, **P < 0.01, *P < 0.05
^aHazard ratio for schizophrenia, depression, and bipolar disorder is not shown because of extremely wide non-significant confidence intervals due to low prevalence
^bReferent group: those without lipid disorder and without any statin prescription

ISSN: 1741-7015