Association between antipsychotic use and acute ischemic heart disease in women but not in men: a retrospective cohort study of over one million primary care patients

Table 3 Adjusted hazard ratios [95% confidence intervals] of acute ischemic heart disease estimated from a mixed-effects Cox model with the specification of the interaction between antipsychotic use and sex

*Antipsychotic prescription for women*^a	1.43 [1.13, 1.79]**
*Men who were not on antipsychotics*^a	2.21 [2.11, 2.31]***
*Men with antipsychotic prescription*^a	2.16 [1.67, 2.80]***
Age (in 10 years)	1.86 [1.83, 1.90]***
Antidepressant prescription	1.15 [1.01, 1.32]*
International Classification of Primary Care Diagnoses as baseline^b
Dementia	0.76 [0.48, 1.22]
Tobacco abuse	1.67 [1.40, 2.01]***
Diabetes	1.43 [1.35, 1.50]***
Hypertension	1.55 [1.47, 1.62]***
Atrial fibrillation	1.16 [0.90, 1.49]
Stroke	1.37 [1.20, 1.55]***
Lipid disorder without any statin prescription^c	1.14 [1.06, 1.23]***
Statin prescription for those without lipid disorder^c	1.59 [1.47, 1.73]***
Lipid disorder with statin prescription^c	0.69 [0.60, 0.79]***

***P < 0.001, **P < 0.01, *P < 0.05
^aReferent group: women who were not on antipsychotics
^bHazard ratio for schizophrenia, depression, and bipolar disorder is not shown because of extremely wide non-significant confidence intervals due to low prevalence
^cReferent group: those without lipid disorder and without any statin prescription

ISSN: 1741-7015