Fig. 1
Comparison of bADA levels and nADA titers. The orange dashed line indicates the cutoff at a log10 bADA level of 1.442256, which optimized the maximum sensitivity and specificity in the discovery data. This cutoff had a sensitivity = 0.83 and a specificity = 0.82 in the discovery dataset; a sensitivity = 0.85 and a specificity = 0.84 in the replication dataset; and a sensitivity = 0.84 and a specificity = 0.82 in the combined dataset. a Density plot showing log10 bADA levels in the combined discovery and replication dataset stratified by nADA presence. b Density plot showing log10 bADA levels in the replication data stratified by nADA presence. c Density plot showing rank-based inverse-normal transformed bADA levels in the combined dataset stratified by nADA presence. d Comparison of log10 bADA levels to log10 nADA titers in the combined dataset, colored by nADA presence