Table 6 Association of candidate variants
Measurement | SNP/HLA allele | First publication | Published effect direction | OR/β (pooled) | p(one-sided) (all prep.) | p(one-sided) (IFNβ-1a s.c.) | p(one-sided) (IFNβ-1b s.c.) |
|---|---|---|---|---|---|---|---|
nADA presence | rs2454138-A | [15] | risk | 1.40OR | 1.59 × 10−05 | 9.65 × 10−01 | 2.41 × 10−16 |
nADA presence | rs522308-T | [15] | risk | 1.39OR | 2.06 × 10−05 | 9.80 × 10−01 | 8.76 × 10−17 |
nADA presence | rs9272105-A | [14] | protective | 0.62OR | 1.21 × 10−13 | 2.76 × 10−12 | 1.14 × 10−05 |
nADA presence | HLA-DQA1*02:01 | [16] | risk | 1.27OR | 2.12 × 10−02 | 5.74 × 10−01 | 2.99 × 10−04 |
nADA presence | HLA-DRB1*04:01 | [12] | risk | 1.76OR | 9.46 × 10−06 | 8.71 × 10−01 | 1.62 × 10−19 |
nADA titer | HLA-DRB1*04:08 | [12] | risk | 1.14β | 7.50 × 10−09 | 1.56 × 10−05 | 6.21 × 10−05 |
nADA titer in nADA-positive | HLA-DRB1*04:08 | [12] | risk | 0.48β | 2.32 × 10−03 | 2.45 × 10−02 | 3.59 × 10−04 |
nADA presence | HLA-DRB1*07:01 | [10] | risk | 1.28OR | 1.90 × 10−02 | 5.47 × 10−01 | 3.03 × 10−04 |
nADA presence | HLA-DRB1*08:01 | [13] | risk | 1.38OR | 2.52 × 10−02 | 1.66 × 10−05 | 9.14 × 10−01 |
nADA presence | HLA-DRB1*15:01 | [13] | risk | 1.32OR | 6.27 × 10−05 | 4.24 × 10−19 | 1.00 × 100 |
bADA levels | HLA-DRB1*16:01 | [11] | risk | 0.54β | 7.10 × 10−06 | 1.12 × 10−02 | 3.34 × 10−05 |
nADA titer in nADA-positive | HLA-DRB1*16:01 | [11] | risk | 0.62β | 2.11 × 10−04 | 2.93 × 10−01 | 5.07 × 10−05 |
nADA presence | HLA-DQA1*05:01 | protective | 0.68OR | 3.09 × 10−07 | 3.15 × 10−09 | 4.59 × 10−03 | |
nADA presence | HLA-DQB1*02:01 | [16] | protective | 0.65OR | 6.24 × 10−06 | 1.46 × 10−09 | 1.94 × 10−01 |
nADA presence | HLA-DRB1*03:01 | protective | 0.65OR | 5.43 × 10−06 | 1.55 × 10−09 | 1.83 × 10−01 | |
nADA presence | HLA-DRB1*04:04 | [11] | protective | 0.56OR | 2.29 × 10−03 | 6.91 × 10−03 | 1.03 × 10−01 |