Table 1 Comparison of characteristics of antiretroviral therapy enrollees between internal derivation, internal validation, and external validation datasets
|  |  | Internal derivation dataset (N = 2838) | Internal validation dataset (N = 2715) | External validation dataset (TB Fast Track, SA; N = 1077)a | |||
|---|---|---|---|---|---|---|---|
Demographics | Â | n | Median or % | n | Median or % | n | Median or % |
 Age, years, median (IQR) |  | 2838 | 33.8 (28.6–40.9) | 2715 | 34.0 (28.6–41.4) | 1077 | 38.0 (32.0–44.0) |
 Female, n, % |  | 1938 | 68% | 1779 | 66% | 590 | 55% |
 If female, pregnant, n, % |  | 520 | 27% | 551 | 31% | 0 | 0% |
 Marital status, n, % | Married/civil union | 300 | 11% | 265 | 10% |  |  |
Single | 2441 | 86% | 2346 | 86% | Â | Â | |
Widowed/divorced | 97 | 3% | 104 | 4% | Â | Â | |
 Smoking history (ever smoked), n, % | 517 | 18% | 551 | 20% | 238 | 22% | |
 Currently employed, n, % |  | 1270 | 45% | 1286 | 47% |  |  |
 Education, n, % | None | 196 | 7% | 200 | 7% |  |  |
Primary | 687 | 24% | 596 | 22% | Â | Â | |
Secondary | 1734 | 61% | 1641 | 60% | Â | Â | |
Higher | 221 | 8% | 278 | 10% | Â | Â | |
HIV/TB history | |||||||
 Previous TB treatment, n, % | Yes | 277 | 10% | 262 | 10% |  |  |
 WHO TB symptoms, n, % | |||||||
  Cough | Yes | 495 | 17% | 547 | 20% | 463 | 43% |
  Weight loss | Yes | 599 | 21% | 555 | 20% | 797 | 74% |
  Fever | Yes | 259 | 9% | 245 | 9% | 314 | 29% |
  Night sweats | Yes | 273 | 10% | 253 | 9% | 348 | 32% |
 Number of WHO TB symptoms, n, % | 0 | 1975 | 70% | 1911 | 70% | 230 | 21% |
1 | 427 | 15% | 349 | 13% | 285 | 26% | |
2 | 202 | 7% | 216 | 8% | 226 | 21% | |
3 | 141 | 5% | 137 | 5% | 178 | 17% | |
4 | 93 | 3% | 102 | 4% | 158 | 15% | |
Clinical characteristics | |||||||
 WHO stage III/IV, n, % |  | 354 | 12% | 307 | 11% |  |  |
 CD4 (cells/μL) | Median (IQR) | 2838 | 245 (143–315) | 2715 | 240 (134–319) | 1077 | 72 (36–110) |
 Weight (kilograms) | Median (IQR) | 2838 | 58.8 (51.8–68.2) | 2715 | 59.7 (52.8–69.0) | 1077 | 57.9 (50.8–67.0) |
 BMI (weight/height²) | Median (IQR) | 2838 | 21.5 (18.9–24.9) | 2715 | 21.6 (19.1–25.0) | 1077 | 21.3 (18.8–25.0) |
 Hemoglobin (g/dL) | Median (IQR) | 2838 | 11.9 (10.4–13.2) | 2715 | 12.0 (10.7–13.4) | 1077 | 11.3 (9.7–13.0) |
 Temperature (degrees Celsius) | Median (IQR) | 2838 | 36.2 (35.8–36.5) | 2715 | 36.2 (35.8–36.6) | 1077 | 36.4 (36.0–36.7) |
 Respiratory rate (breaths/min) | Median (IQR) | 2838 | 19 (18–20) | 2715 | 19 (18–20) |  |  |
 Heart rate (beats/min) | Median (IQR) | 2838 | 84 (75–94) | 2715 | 84 (75–95) |  |  |
Mortality within 6 months | |||||||
 Cumulative incidence, n, % |  | 83 | 2.9% | 67 | 2.5% | 60 | 6% |
 Time to death (days) |  Median (IQR) | 83 | 50 (25–105) | 67 | 46 (16–87) | 60 | 55 (30–112) |