| Alive/TF by 6 months of ART (N = 2755) | Died by 6 months of ART (N = 83) | Unadjusted | Model A—adjusted model excluding CD4 | Model B—adjusted model including CD4 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | N | Median (IQR)/% | n | N | Median (IQR)/% | OR | 95% CI | p | AOR | 95% CI | p | AOR | 95% CI | p | ||
Demographics | ||||||||||||||||
 Age, years (for every 10-year increase) |  | 2755 | 34 (29–41) |  | 83 | 39 (31–49) | 1.44 | (1.19–1.73) | < 0.001 |  |  |  |  |  |  | |
 Sex and pregnancy status | Pregnant | 517 | 520 | 99% | 3 | 520 | 1% | 1.00 | – | – | 1.00 | – | – | 1.00 | – | – |
Female non-pregnant | 1379 | 1418 | 97% | 39 | 1418 | 3% | 4.87 | (1.66–14.3) | 0.004 | 2.45 | (0.76–7.88) | 0.133 | 2.04 | (0.68–6.09) | 0.201 | |
Male | 859 | 900 | 95% | 41 | 900 | 5% | 8.23 | (2.72–24.91) | < 0.001 | 5.47 | (1.49–20.17) | 0.011 | 4.35 | (1.27–14.88) | 0.019 | |
 Marital status | Married/civil union | 292 | 300 | 97% | 8 | 300 | 3% | 1.00 | – | – |  |  |  |  |  |  |
Single | 2367 | 2441 | 97% | 74 | 2441 | 3% | 1.14 | (0.65–2) | 0.646 |  |  |  |  |  |  | |
Widowed/divorced | 96 | 97 | 99% | 1 | 97 | 1% | 0.38 | (0.05–3.14) | 0.369 |  |  |  |  |  |  | |
 Smoking history | Never | 2262 | 2321 | 97% | 59 | 2321 | 3% | 1.00 | – | – |  |  |  |  |  |  |
Current/ex-smoker | 493 | 517 | 95% | 24 | 517 | 5% | 1.87 | (1.11–3.15) | 0.019 |  |  |  |  |  |  | |
 Employed | Employed | 1233 | 1270 | 97% | 37 | 1270 | 3% | 1.00 | – | – |  |  |  |  |  |  |
Unemployed | 1522 | 1568 | 97% | 46 | 1568 | 3% | 1.01 | (0.68–1.48) | 0.971 |  |  |  |  |  |  | |
 Education | None | 188 | 196 | 96% | 8 | 196 | 4% | 1.00 | – | – |  |  |  |  |  |  |
Primary | 664 | 687 | 97% | 23 | 687 | 3% | 0.81 | (0.36–1.85) | 0.610 |  |  |  |  |  |  | |
Secondary | 1687 | 1734 | 97% | 47 | 1734 | 3% | 0.65 | (0.31–1.39) | 0.265 |  |  |  |  |  |  | |
Higher | 216 | 221 | 98% | 5 | 221 | 2% | 0.54 | (0.23–1.26) | 0.300 |  |  |  |  |  |  | |
HIV/TB history | ||||||||||||||||
 Previous TB treatment | No | 2489 | 2561 | 97% | 72 | 2561 | 3% | 1.00 | – | – |  |  |  |  |  |  |
Yes | 266 | 277 | 96% | 11 | 277 | 4% | 1.43 | (0.74–2.77) | 0.290 |  |  |  |  |  |  | |
 Number of WHO TB symptoms | 0 | 1955 | 1975 | 99% | 20 | 1975 | 1% | 1.00 | – | – | 1.00 | – | – | 1.00 | – | – |
1 | 407 | 427 | 95% | 20 | 427 | 5% | 4.80 | (2.8–8.23) | < 0.001 | 3.39 | (1.88–6.09) | < 0.001 | 3.16 | (1.84–5.43) | < 0.001 | |
2 | 188 | 202 | 93% | 14 | 202 | 7% | 7.28 | (3.58–14.8) | < 0.001 | 4.03 | (1.82–8.92) | 0.001 | 3.64 | (1.63–8.12) | 0.002 | |
3 or 4 | 205 | 234 | 88% | 29 | 234 | 12% | 13.83 | (9.04–21.13) | < 0.001 | 5.05 | (3.31–7.7) | < 0.001 | 4.68 | (2.93–7.48) | < 0.001 | |
Clinical characteristics | ||||||||||||||||
 WHO stage | I/II | 2441 | 2484 | 98% | 43 | 2484 | 2% | 1.00 | – | – | 1.00 | – | – | 1.00 | – | – |
III/IV | 314 | 354 | 89% | 40 | 354 | 11% | 7.23 | (3.87–13.52) | < 0.001 | 2.57 | (1.32–4.99) | 0.005 | 2.47 | (1.24–4.89) | 0.010 | |
 CD4 (per 10-cell increase)a |  | 2755 | 249 (149–317) |  | 83 | 98 (41–218) | 0.94 | (0.9–0.98) | 0.002 |  |  |  | 0.98 | (0.95–1.01) | 0.211 | |
 Weight (per 1-kg increase)b |  | 2755 | 59 (52–68) |  | 83 | 51 (45–60) | 0.96 | (0.93–0.98) | 0.001 |  |  |  |  |  |  | |
 BMI (per 1-unit increase)b |  | 2755 | 21.6 (19.0–25.0) |  | 83 | 19.0 (17.0–21.8) | 0.86 | (0.79–0.94) | 0.001 |  |  |  |  |  |  | |
 Hemoglobin (per 1-g/dL increase) |  | 2755 | 11.9 (10.5–13.3) |  | 83 | 9.9 (8.5–11.7) | 0.69 | (0.61–0.79) | < 0.001 | 0.73 | (0.65–0.81) | < 0.001 | 0.74 | (0.67–0.81) | < 0.001 | |
 Temperature (per 1 °C increase)c |  | 2755 | 36.2 (35.8–36.5) |  | 83 | 36.5 (36.0–37.0) | 2.09 | (1.47–2.96) | < 0.001 | 1.26 | (0.96–1.65) | 0.092 | 1.25 | (0.94–1.67) | 0.127 | |
 Heart rate (per 1 beat/min increase)d |  | 2755 | 84 (75–94) |  | 83 | 102 (85–121) | 1.05 | (1.04–1.06) | < 0.001 |  |  |  |  |  |  | |
 Respiratory rate (per 1 breath/min increase) |  | 2755 | 18 (18–20) |  | 83 | 20 (18–22) | 1.02 | (1.01–1.04) | 0.009 |  |  |  |  |  |  |