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Table 3 MR estimates from different methods of assessing the causal effect of CD on BMDs

From: Mendelian randomization study of inflammatory bowel disease and bone mineral density

BMDs Step# No. of SNP IVW MBE WMM MR-Egger MR.RAPS
β (95%CI) P value Cochran Q statistics (df) P value β (95%CI) P value β (95%CI) P value Slope (95%CI) P value Intercept (Se) P value Cochran Q statistics (df) P value β (95%CI) P value
CD and TB-BMD 3 103 − 0.0061 (− 0.016, 0.0040) 0.24 107.79 (102) 0.33 0.0071 (− 0.016, 0.031) 0.55 − 0.0018 (− 0.017, 0.013) 0.81 0.0047 (− 0.024, 0.033) 0.75 − 0.0015 (0.0019) 0.43 107.12 (101) 0.32 − 0.0049 (− 0.015, 0.0056) 0.36
CD and FN-BMD 3 104 − 0.019 (− 0.034, − 0.0050) 0.0083 127.33 (103) 0.052 − 0.0030 (− 0.036, 0.030) 0.86 − 0.019 (− 0.039, 0.0024) 0.082 0.0066 (− 0.033, 0.046) 0.74 − 0.0036 (0.0026) 0.17 125.00 (102) 0.061 − 0.017 (− 0.032, − 0.0019) 0.027
CD and LS-BMD 2 107 − 0.0048 (− 0.021, 0.011) 0.55 125.92 (106) 0.091 − 0.025 (− 0.064, 0.014) 0.21 − 0.020 (− 0.042, 0.0030) 0.089 0.0084 (− 0.036, 0.053) 0.71 − 0.0018 (0.0030) 0.53 125.45 (105) 0.085 − 0.0049 (− 0.021, 0.011) 0.54
CD and FA-BMD 3 108 0.010 (− 0.018) 0.48 123.69 (107) 0.13 0.035 (− 0.022, 0.092) 0.23 0.018 (− 0.023, 0.060) 0.39 0.073 (− 0.0039, 0.15) 0.066 − 0.0088 (0.0051) 0.088 120.33 (106) 0.16 0.013 (− 0.016, 0.042) 0.38
CD and TB-BMD(R*) 3 92 − 0.0072 (− 0.018, 0.0032) 0.17 103.94 (91) 0.17 − 0.0082 (− 0.028, 0.012) 0.43 − 0.0096 (− 0.027, 0.0082) 0.29 − 0.012 (− 0.037, 0.012) 0.32 0.00080 (0.0017) 0.64 103.69 (90) 0.15 − 0.0070 (− 0.018, 0.0037) 0.20
CD and FN-BMD(R*) 3 90 − 0.022 (− 0.036, − 0.0072) 0.0034 111.59 (89) 0.053 − 0.033 (− 0.061, − 0.0062) 0.018 − 0.028 (− 0.051, − 0.0049) 0.018 − 0.015 (− 0.047, 0.018) 0.39 − 0.0011 (0.0023) 0.63 111.30 (88) 0.047 − 0.023 (− 0.038, − 0.0073) 0.0039
CD and LS-BMD(R*) 3 84 − 0.0022 (− 0.018, 0.013) 0.78 78.79 (83) 0.61 − 0.018 (− 0.051, 0.015) 0.28 − 0.015 (− 0.041, 0.010) 0.24 0.0024 (− 0.032, 0.036) 0.89 − 0.00071 (0.0024) 0.77 78.71 (82) 0.58 − 0.0017 (− 0.018, 0.014) 0.84
CD and FA-BMD(R*) 3 95 − 0.0095 (− 0.036, 0.017) 0.49 98.95 (94) 0.34 0.0012 (− 0.056, 0.058) 0.97 0.00063 (− 0.039, 0.041) 0.98 0.0062 (− 0.056, 0.069) 0.85 − 0.0024 (0.0044) 0.59 98.64 (93) 0.32 − 0.0066 (− 0.035, 0.021) 0.64
  1. Step#: 2, MR analysis after removing the SNPs (with P value less than threshold in MR-PRESSO outlier test); 3, MR analysis after removing all the SNPs (with P value less than 1 in MR-PRESSO outlier test); R*, in replication practice
  2. TB-BMD total body bone mineral density, FN-BMD femoral neck bone mineral density, LS-BMD lumbar spine bone mineral density, FA-BMD forearm bone mineral density, β beta coefficient, Se standard error, SNP single nucleotide polymorphism, MR Mendelian randomization, IVW inverse variance weighting, MR-PRESSO MR-Pleiotropy RESidual Sum and Outlier method, MBE mode-based estimate method, WMM weighted median method, MR.RAPS robust adjusted profile score