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Table 3 MR estimates from different methods of assessing the causal effect of CD on BMDs

From: Mendelian randomization study of inflammatory bowel disease and bone mineral density

BMDs

Step#

No. of SNP

IVW

MBE

WMM

MR-Egger

MR.RAPS

β (95%CI)

P value

Cochran Q statistics (df)

P value

β (95%CI)

P value

β (95%CI)

P value

Slope (95%CI)

P value

Intercept (Se)

P value

Cochran Q statistics (df)

P value

β (95%CI)

P value

CD and TB-BMD

3

103

− 0.0061 (− 0.016, 0.0040)

0.24

107.79 (102)

0.33

0.0071 (− 0.016, 0.031)

0.55

− 0.0018 (− 0.017, 0.013)

0.81

0.0047 (− 0.024, 0.033)

0.75

− 0.0015 (0.0019)

0.43

107.12 (101)

0.32

− 0.0049 (− 0.015, 0.0056)

0.36

CD and FN-BMD

3

104

− 0.019 (− 0.034, − 0.0050)

0.0083

127.33 (103)

0.052

− 0.0030 (− 0.036, 0.030)

0.86

− 0.019 (− 0.039, 0.0024)

0.082

0.0066 (− 0.033, 0.046)

0.74

− 0.0036 (0.0026)

0.17

125.00 (102)

0.061

− 0.017 (− 0.032, − 0.0019)

0.027

CD and LS-BMD

2

107

− 0.0048 (− 0.021, 0.011)

0.55

125.92 (106)

0.091

− 0.025 (− 0.064, 0.014)

0.21

− 0.020 (− 0.042, 0.0030)

0.089

0.0084 (− 0.036, 0.053)

0.71

− 0.0018 (0.0030)

0.53

125.45 (105)

0.085

− 0.0049 (− 0.021, 0.011)

0.54

CD and FA-BMD

3

108

0.010 (− 0.018)

0.48

123.69 (107)

0.13

0.035 (− 0.022, 0.092)

0.23

0.018 (− 0.023, 0.060)

0.39

0.073 (− 0.0039, 0.15)

0.066

− 0.0088 (0.0051)

0.088

120.33 (106)

0.16

0.013 (− 0.016, 0.042)

0.38

CD and TB-BMD(R*)

3

92

− 0.0072 (− 0.018, 0.0032)

0.17

103.94 (91)

0.17

− 0.0082 (− 0.028, 0.012)

0.43

− 0.0096 (− 0.027, 0.0082)

0.29

− 0.012 (− 0.037, 0.012)

0.32

0.00080 (0.0017)

0.64

103.69 (90)

0.15

− 0.0070 (− 0.018, 0.0037)

0.20

CD and FN-BMD(R*)

3

90

− 0.022 (− 0.036, − 0.0072)

0.0034

111.59 (89)

0.053

− 0.033 (− 0.061, − 0.0062)

0.018

− 0.028 (− 0.051, − 0.0049)

0.018

− 0.015 (− 0.047, 0.018)

0.39

− 0.0011 (0.0023)

0.63

111.30 (88)

0.047

− 0.023 (− 0.038, − 0.0073)

0.0039

CD and LS-BMD(R*)

3

84

− 0.0022 (− 0.018, 0.013)

0.78

78.79 (83)

0.61

− 0.018 (− 0.051, 0.015)

0.28

− 0.015 (− 0.041, 0.010)

0.24

0.0024 (− 0.032, 0.036)

0.89

− 0.00071 (0.0024)

0.77

78.71 (82)

0.58

− 0.0017 (− 0.018, 0.014)

0.84

CD and FA-BMD(R*)

3

95

− 0.0095 (− 0.036, 0.017)

0.49

98.95 (94)

0.34

0.0012 (− 0.056, 0.058)

0.97

0.00063 (− 0.039, 0.041)

0.98

0.0062 (− 0.056, 0.069)

0.85

− 0.0024 (0.0044)

0.59

98.64 (93)

0.32

− 0.0066 (− 0.035, 0.021)

0.64

  1. Step#: 2, MR analysis after removing the SNPs (with P value less than threshold in MR-PRESSO outlier test); 3, MR analysis after removing all the SNPs (with P value less than 1 in MR-PRESSO outlier test); R*, in replication practice
  2. TB-BMD total body bone mineral density, FN-BMD femoral neck bone mineral density, LS-BMD lumbar spine bone mineral density, FA-BMD forearm bone mineral density, β beta coefficient, Se standard error, SNP single nucleotide polymorphism, MR Mendelian randomization, IVW inverse variance weighting, MR-PRESSO MR-Pleiotropy RESidual Sum and Outlier method, MBE mode-based estimate method, WMM weighted median method, MR.RAPS robust adjusted profile score