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Fig. 3 | BMC Medicine

Fig. 3

From: Impact of the common MTHFR 677C→T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project

Fig. 3

Influence of riboflavin status on the risk of hypertension by MTHFR genotype. Values are odds ratios (95% confidence intervals) for risk of hypertension for CC (left panel, green), CT (middle panel, amber) or TT (right panel, red) genotypes for the MTHFR 677C→T polymorphism. Data analysed by multinomial regression adjusted for relevant covariates: age, sex, BMI, alcohol, antihypertensive drug use, total cholesterol, creatinine, smoking, study cohort, plasma homocysteine, red blood cell folate. Compared to the reference category (CC genotype combined with normal riboflavin status), values for the TT genotype combined with deficient riboflavin status are OR 3.00 (95% CI, 1.34–6.68; P = 0.007); or with low riboflavin status: OR 1.62 (0.80–3.29; P = 0.179); or with normal riboflavin status: OR 0.98 (0.47–2.04; P = 0.957). Riboflavin status determined by the functional biomarker, erythrocyte glutathione reductase activation coefficient (EGRac); participants categorised as having normal (EGRac ≤ 1.26; filled circles), low (EGRac > 1.26 to < 1.40; open circles) or deficient (EGRac ≥ 1.40; open squares) riboflavin status

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