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Table 2 Factors associated with risk of hypertension in adults 18–70 years

From: Impact of the common MTHFR 677C→T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project

  All (n = 2566) On antihypertensive drugs (n = 1255) Not on antihypertensive drugs (n = 1311)
OR 95% CI Pb OR 95% CI Pb OR 95% CI Pa
Age, years 1.04 1.03–1.05 < 0.001 1.01 0.98–1.04 0.568 1.05 1.03–1.06 < 0.001
Sex, male 1.86 1.50–2.32 < 0.001 1.69 1.28–2.25 0.001 1.77 1.23–2.56 0.002
BMI, kg/m2 1.06 1.04–1.08 < 0.001 1.03 1.01–1.05 0.009 1.11 1.07–1.15 < 0.001
Alcohol intake, units per week 1.01 1.00–1.02 0.005 1.01 1.00–1.02 0.325 1.03 1.01–1.04 < 0.001
Antihypertensive medication useb 2.01 1.60–2.52 < 0.001       
Serum creatinine, μmol/L 1.00 0.99–1.00 0.307 1.00 0.99–1.00 0.189 1.01 0.99–1.02 0.340
Total cholesterol, mmol/L 1.26 1.15–1.38 < 0.001 1.25 1.11–1.41 < 0.001 1.23 1.07–1.41 0.004
Smoking
 Past 0.98 0.80–1.19 0.826 0.97 0.75–1.26 0.834 1.02 0.74–1.41 0.888
 Current 1.03 0.79–1.33 0.845 0.92 0.64–1.31 0.630 1.10 0.75–1.62 0.618
Study cohortc 1.79 1.29–2.48 < 0.001 2.40 1.40–4.11 < 0.001 2.09 1.31–3.32 0.002
Plasma homocysteine, μmol/L 1.00 0.98–1.02 0.958 0.98 0.96–1.00 0.074 1.06 1.02–1.10 0.002
MTHFR genotyped
 CT 1.18 0.98–1.43 0.082 1.35 1.05–1.73 0.018 0.98 0.73–1.32 0.889
 TT 1.42 1.07–1.90 0.016 1.40 0.95–2.06 0.093 1.37 0.88–2.11 0.161
  1. CI confidence interval, OR odds ratio
  2. aData analysed by logistic regression to predict hypertension as the categorical dependent variable; hypertension defined as systolic BP of ≥ 140 and/or a diastolic BP of ≥ 90 mmHg [1]
  3. bAs a binary (yes/no) covariate
  4. cComparing TUDA cohort with NANS cohort (reference category). See supplementary Table S1 for participant characteristics presented separately for each study cohort
  5. dCT (heterozygous) and TT (homozygous variant) genotypes for the MTHFR 677C→T polymorphism; reference category is the CC genotype