Impact of the common MTHFR 677C→T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project

Table 3 Blood pressure and rates of hypertension in adulthood by MTHFR genotype

CC (wild type), CT (heterozygous), TT (homozygous variant), genotypes for the MTHFR 677C→T polymorphism
Data are expressed as mean (95% CI) for age, as adjusted mean (95% CI) for blood pressure, and n (%) for hypertension
BP blood pressure
^aHypertension defined as systolic BP of ≥ 140 and/or a diastolic BP of ≥ 90 mmHg [1]
^bDifferences in blood pressure between genotype groups were assessed by one-way ANCOVA with adjustment for age, sex, BMI, alcohol, total cholesterol, antihypertensive drugs use and study cohort following log-transformation of data for normalisation purposes, as appropriate. Different superscript letters (i.e. a, b) within a row indicate significant differences by Bonferroni post hoc test, whilst the same letter (i.e. a, a) indicates no significant differences. Categorical variables were assessed using chi-square analysis

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