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Table 3 Blood pressure and rates of hypertension in adulthood by MTHFR genotype

From: Impact of the common MTHFR 677C→T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project

  MTHFR genotype  
CC CT TT P valueb
Total cohort (up to 90 years) n = 2635 n = 2606 n = 719  
 Age, years 68.9 (68.3, 69.5) 69.0 (68.4, 69.6) 68.6 (67.5, 69.7) 0.806
 Systolic BP, mmHg 140.7 (139.8, 141.5) 141.5 (140.8, 142.4) 141.1 (139.6, 142.6) 0.373
 Diastolic BP, mmHg 78.0 (77.6, 78.4) 78.5 (78.0, 78.9) 78.4 (77.6, 79.2) 0.258
 Hypertension, n (%) 1373 (51%) 1411 (53%) 373 (50%) 0.302
Adults 18 to 70 years n = 1124 n = 1138 n = 313  
 Age, years 56.3 (55.4, 57.1) 56.4 (55.6, 57.3) 55.8 (54.2, 57.5) 0.835
 Systolic BP, mmHg 135.0 (133.9, 136.0)a 136.1 (135.0, 137.2)ab 137.6 (135.5, 139.6)b 0.026
 Diastolic BP, mmHg 79.4 (78.9, 80.0)a 80.0 (79.4, 80.5)ab 81.4 (80.3, 82.5)b 0.013
 Hypertension, n (%) 464 (40) 514 (44) 149 (46) 0.072
  1. CC (wild type), CT (heterozygous), TT (homozygous variant), genotypes for the MTHFR 677C→T polymorphism
  2. Data are expressed as mean (95% CI) for age, as adjusted mean (95% CI) for blood pressure, and n (%) for hypertension
  3. BP blood pressure
  4. aHypertension defined as systolic BP of ≥ 140 and/or a diastolic BP of ≥ 90 mmHg [1]
  5. bDifferences in blood pressure between genotype groups were assessed by one-way ANCOVA with adjustment for age, sex, BMI, alcohol, total cholesterol, antihypertensive drugs use and study cohort following log-transformation of data for normalisation purposes, as appropriate. Different superscript letters (i.e. a, b) within a row indicate significant differences by Bonferroni post hoc test, whilst the same letter (i.e. a, a) indicates no significant differences. Categorical variables were assessed using chi-square analysis