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Table 4 Antihypertensive drug use in treated participants up to 70 years

From: Impact of the common MTHFR 677C→T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project

  MTHFR genotype
CC (n = 536) CT (n = 590) TT (n = 154)
Drug class
 ARB 149 (28) 167 (28) 53 (34)
 ACE 185 (35) 221 (37) 52 (34)
 CCB 188 (35) 207 (35) 61 (40)
 Diuretic 224 (42) 260 (44) 59 (39)
 β-Blocker 180 (34) 187 (32) 54 (35)
 α-Blocker 38 (7) 35 (6) 7 (5)
 Central alpha antagonist 3 (1) 6 (1) 2 (1)
Drug combination
 1 medication 230 (43) 257 (44) 64 (41)
 2 medications 200 (37) 205 (35) 52 (34)
 ≥ 3 medications 106 (20) 128 (22) 38 (25)
  1. Values are n (%)
  2. CC (wild type), CT (heterozygous), TT (homozygous variant), genotypes for the MTHFR 677C→T polymorphism
  3. ARB angiotensin II receptor blockers, ACE angiotensin-converting enzyme, CCB calcium-channel blockers