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Table 4 Antihypertensive drug use in treated participants up to 70 years

From: Impact of the common MTHFR 677C→T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project

 

MTHFR genotype

CC (n = 536)

CT (n = 590)

TT (n = 154)

Drug class

 ARB

149 (28)

167 (28)

53 (34)

 ACE

185 (35)

221 (37)

52 (34)

 CCB

188 (35)

207 (35)

61 (40)

 Diuretic

224 (42)

260 (44)

59 (39)

 β-Blocker

180 (34)

187 (32)

54 (35)

 α-Blocker

38 (7)

35 (6)

7 (5)

 Central alpha antagonist

3 (1)

6 (1)

2 (1)

Drug combination

 1 medication

230 (43)

257 (44)

64 (41)

 2 medications

200 (37)

205 (35)

52 (34)

 ≥ 3 medications

106 (20)

128 (22)

38 (25)

  1. Values are n (%)
  2. CC (wild type), CT (heterozygous), TT (homozygous variant), genotypes for the MTHFR 677C→T polymorphism
  3. ARB angiotensin II receptor blockers, ACE angiotensin-converting enzyme, CCB calcium-channel blockers